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The antimicrobial activity of the compounds indicated that <jats:italic>N<\/jats:italic>\u2010{5\u2010[<jats:italic>N<\/jats:italic>\u2010(2\u2010{[4\u2010(4\u2010chloro\u20101<jats:italic>H<\/jats:italic>\u2010pyrrol\u20102\u2010yl)\u20101<jats:italic>H<\/jats:italic>\u2010imidazol\u20102\u2010yl)amino}\u20102\u2010oxoethyl)sulfamoyl]\u20104\u2010phenylthiazol\u20102\u2010yl}benzamide (<jats:bold>22a<\/jats:bold>), <jats:italic>N<\/jats:italic>\u2010{5\u2010[<jats:italic>N<\/jats:italic>\u2010(2\u2010{[4\u2010(4\u2010chloro\u20101<jats:italic>H<\/jats:italic>\u2010pyrrol\u20102\u2010yl)\u20101<jats:italic>H<\/jats:italic>\u2010imidazol\u20102\u2010yl]amino}\u20102\u2010oxoethyl)sulfamoyl]\u20104\u2010(4\u2010chlorophenyl)thiazol\u20102\u2010yl}benzamide (<jats:bold>22c<\/jats:bold>), and <jats:italic>N<\/jats:italic>\u2010{5\u2010[<jats:italic>N<\/jats:italic>\u2010(2\u2010{[4\u2010(4\u2010chloro\u20101<jats:italic>H<\/jats:italic>\u2010pyrrol\u20102\u2010yl)\u20101<jats:italic>H<\/jats:italic>\u2010imidazol\u20102\u2010yl]amino}\u20102\u2010oxoethyl)sulfamoyl]\u20104\u2010(4\u2010chloro\u2010phenyl)\u20101<jats:italic>H<\/jats:italic>\u2010imidazol\u20102\u2010yl}benzamide (<jats:bold>24c<\/jats:bold>) exhibited a low minimal inhibitory concentration (MIC) against <jats:italic>Bacillus subtilis<\/jats:italic>, equal to the standard drug, chloramphenicol. Compounds <jats:bold>22c<\/jats:bold> and <jats:bold>24c<\/jats:bold> also showed low MICs against <jats:italic>Aspergillus niger<\/jats:italic>, equal to the standard drug, ketoconazole. The molecular properties of the synthesized molecules were studied to identify druglikeness properties of the target compounds. On the basis of molecular properties prediction, <jats:bold>19a<\/jats:bold>, <jats:bold>19b<\/jats:bold>, <jats:bold>20b<\/jats:bold>, <jats:bold>20c<\/jats:bold>, <jats:bold>21a<\/jats:bold>\u2013<jats:bold>c<\/jats:bold>, <jats:bold>22b<\/jats:bold>, <jats:bold>22c<\/jats:bold>, and <jats:bold>23a<\/jats:bold>\u2013<jats:bold>c<\/jats:bold> can be treated as drug candidates.<\/jats:p>","DOI":"10.1002\/ardp.202000483","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T03:55:19Z","timestamp":1620791719000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Molecular properties prediction, synthesis, and antimicrobial activity of bis(azolyl)sulfonamidoacetamides"],"prefix":"10.1002","volume":"354","author":[{"given":"Siva sankar","family":"P","sequence":"first","affiliation":[{"name":"Department of Chemistry Sri Venkateswara University  Tirupati Andhra Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narendra babu","family":"K","sequence":"additional","affiliation":[{"name":"Department of Chemistry Sri Venkateswara University  Tirupati Andhra Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamatam","family":"Rekha","sequence":"additional","affiliation":[{"name":"Department of Chemistry Sri Venkateswara University  Tirupati Andhra Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4015-8163","authenticated-orcid":false,"given":"Adivireddy","family":"Padmaja","sequence":"additional","affiliation":[{"name":"Department of Chemistry Sri Venkateswara University  Tirupati Andhra Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3448-1423","authenticated-orcid":false,"given":"Venkatapuram","family":"Padmavathi","sequence":"additional","affiliation":[{"name":"Department of Chemistry Sri Venkateswara University  Tirupati Andhra Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,11]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"98","author":"Zhang L.","year":"2013","journal-title":"Med. 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