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We have previously reported (+)\u2010camphor and (\u2212)\u2010borneol derivatives with an antiviral activity against the vaccinia virus. This virus is similar to the variola virus (VARV), the causative agent of smallpox, but can be studied at BSL\u20102 facilities. In the present study, we evaluated the antiviral activity of the most potent compounds against VARV, cowpox virus, and ectromelia virus (ECTV). Among the compounds tested, 4\u2010bromo\u2010<jats:italic>N\u02b9<\/jats:italic>\u2010((1<jats:italic>R<\/jats:italic>,4<jats:italic>R<\/jats:italic>)\u20101,7,7\u2010trimethylbicyclo[2.2.1]heptan\u20102\u2010ylidene)benzohydrazide <jats:bold>18<\/jats:bold> is the most effective compound against various orthopoxviruses, including VARV, with an EC<jats:sub>50<\/jats:sub> value of 13.9\u2009\u03bcM and a selectivity index of 206. Also, (+)\u2010camphor thiosemicarbazone <jats:bold>9<\/jats:bold> was found to be active against VARV and ECTV.<\/jats:p>","DOI":"10.1002\/ardp.202100038","type":"journal-article","created":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T00:28:22Z","timestamp":1613867302000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["(+)\u2010Camphor and (\u2212)\u2010borneol derivatives as potential anti\u2010orthopoxvirus agents"],"prefix":"10.1002","volume":"354","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5227-9996","authenticated-orcid":false,"given":"Anastasiya S.","family":"Sokolova","sequence":"first","affiliation":[{"name":"N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry Siberian Branch Russian Academy of Sciences  Novosibirsk Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kseniya S.","family":"Kovaleva","sequence":"additional","affiliation":[{"name":"N. 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