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Due to the success of silver\u2013NHCs in medicinal applications, interest in these compounds is rapidly increasing. Therefore, the interaction of <jats:italic>N,N<\/jats:italic>\u2010disubstituted benzimidazolium salts with Ag<jats:sub>2<\/jats:sub>O in dichloromethane to prepare novel Ag(I)\u2013NHCs complexes was carried out at room temperature for 120\u2009h in the absence of light. The obtained complexes were identified and characterized by <jats:sup>1<\/jats:sup>H and <jats:sup>13<\/jats:sup>C nuclear magnetic resonance, Fourier\u2010transform infrared, UV\u2013Vis, and elemental analysis techniques. Then, the silver complexes were applied for three\u2010component coupling reactions of aldehydes, amines, and alkynes. The effect of changing the alkyl substituent on the NHCs ligand on the catalytic performance was investigated. In addition, it has been found that the complexes are antimicrobially active and show higher activity than the free ligand. The silver\u2013carbene complexes showed antimicrobial activity against specified microorganisms with MIC values between 0.24 and 62.5\u2009\u03bcg\/ml. These results showed that the silver\u2013NHC complexes exhibit an effective antimicrobial activity against bacterial and fungal strains. A density functional theory calculation study was performed to identify the stability of the obtained complexes. All geometries were optimized employing an effective core potential basis, such as LANL2DZ for the Ag atom and 6\u2010311+G(d,p) for all the other atoms in the gas phase. Electrostatic potential surfaces and LUMO\u2013HOMO energy were computed. Transition energies and excited\u2010state structures were obtained from the time\u2010dependent density functional theory calculations.<\/jats:p>","DOI":"10.1002\/ardp.202100111","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T07:19:10Z","timestamp":1623741550000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Silver\u2013<i>N<\/i>\u2010heterocyclic carbene complexes\u2010catalyzed multicomponent reactions: Synthesis, spectroscopic characterization, density functional theory calculations, and antibacterial study"],"prefix":"10.1002","volume":"354","author":[{"given":"Aziza","family":"Mnasri","sequence":"first","affiliation":[{"name":"Research Laboratory of Environmental Sciences and Technologies (LR16ES09), Higher Institute of Environmental Sciences and Technology University of Carthage  Tunis Tunisia"},{"name":"Catalysis Research and Application Center \u0130n\u00f6n\u00fc University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Mejri","sequence":"additional","affiliation":[{"name":"Research Laboratory of Environmental Sciences and Technologies (LR16ES09), Higher Institute of Environmental Sciences and Technology University of Carthage  Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadeq M.","family":"Al\u2010Hazmy","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science Qassim University  Buraidah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youssef","family":"Arfaoui","sequence":"additional","affiliation":[{"name":"Laboratory of Characterizations, Applications &amp; Modeling of Materials (LR18ES08), Department of Chemistry, Faculty of Sciences University of Tunis El Manar  Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Catalysis Research and Application Center \u0130n\u00f6n\u00fc University  Malatya Turkey"},{"name":"Department of Chemistry, Faculty of Science and Art \u0130n\u00f6n\u00fc University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nevin","family":"G\u00fcrb\u00fcz","sequence":"additional","affiliation":[{"name":"Catalysis Research and Application Center \u0130n\u00f6n\u00fc University  Malatya Turkey"},{"name":"Department of Chemistry, Faculty of Science and Art \u0130n\u00f6n\u00fc University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0110-9588","authenticated-orcid":false,"given":"Naceur","family":"Hamdi","sequence":"additional","affiliation":[{"name":"Research Laboratory of Environmental Sciences and Technologies (LR16ES09), Higher Institute of Environmental Sciences and Technology University of Carthage  Tunis Tunisia"},{"name":"Department of Chemistry, College of Science and Arts Qassim University  Ar Rass Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13384"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4SC03966A"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8OB01667D"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00079"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22111882"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CP00553F"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.200500030"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201501840"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol800824h"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)72045-0"},{"key":"e_1_2_6_12_1","first-page":"1067","volume":"3","author":"Khan M. 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