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The naphthol derivatives were synthesized in three steps, namely the addition reaction of furan via Diels\u2013Alder cycloaddition reaction, copper(II) trifluoromethanesulfonate (Cu(OTf)<jats:sub>2<\/jats:sub>)\u2010catalyzed aromatization reaction, and the bromination reaction, respectively. The structures of the newly obtained compounds (<jats:bold>4c<\/jats:bold>,<jats:bold>d<\/jats:bold>, <jats:bold>5a<\/jats:bold>, <jats:bold>6a<\/jats:bold>, <jats:bold>7a<\/jats:bold>,<jats:bold>b<\/jats:bold>) were characterized by spectroscopic techniques. In addition, some biological activity studies were investigated under in vitro conditions. Inhibition studies of these compounds were performed on human carbonic anhydrase (hCA) I and II isoenzymes purified from human erythrocytes as a biological evaluation. Moreover, their potential antioxidant and antiradical activities were studied by analytical methods like ABTS<jats:sup>\u2022+<\/jats:sup> and DPPH\u2022 scavenging, and it was determined that some molecules showed good activity. Also, inhibition of acetylcholinesterase (AChE), which is a marker of many degenerative neurological diseases, was tested and the results were discussed. Excellent enzyme inhibition results were recorded for most of the molecules. These 1\u2010naphthol derivatives were found as effective inhibitors for hCA I, hCA II, and AChE with <jats:italic>K<\/jats:italic>\n<jats:sub>i<\/jats:sub> values ranging from 0.034\u2009\u00b1\u20090.54 to 0.724\u2009\u00b1\u20090.18\u2009\u00b5M for hCA I, 0.172\u2009\u00b1\u20090.02 to 0.562\u2009\u00b1\u20090.21\u2009\u00b5M for hCA II, and 0.096\u2009\u00b1\u20090.01 to 0.177\u2009\u00b1\u20090.02\u2009\u00b5M for AChE.<\/jats:p>","DOI":"10.1002\/ardp.202100113","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T09:57:47Z","timestamp":1622800667000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Synthesis and biological evaluation of some 1\u2010naphthol derivatives as antioxidants, acetylcholinesterase, and carbonic anhydrase inhibitors"],"prefix":"10.1002","volume":"354","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6097-2862","authenticated-orcid":false,"given":"Musa","family":"Erdo\u011fan","sequence":"first","affiliation":[{"name":"Department of Food Engineering, Faculty of Engineering and Architecture Kafkas University  Kars Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5759-7889","authenticated-orcid":false,"given":"Leyla","family":"Polat K\u00f6se","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, Vocational School Beykent University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2850-4361","authenticated-orcid":false,"given":"Sel\u00e7uk","family":"E\u015fsiz","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences Atat\u00fcrk University  Erzurum Turkey"},{"name":"Department of Chemical Engineering, Faculty of Engineering Hakkari University  Hakkari Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5993-1668","authenticated-orcid":false,"given":"\u0130lhami","family":"G\u00fcl\u00e7in","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences Atat\u00fcrk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/3527608001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22379"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13550"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/np960200h"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00100a042"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm1015395"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000190602.14691.70"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010611-134517"},{"key":"e_1_2_7_10_1","first-page":"57","volume":"778","author":"Smith C. 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