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The human carbonic anhydrase (hCA) I and hCA II enzyme inhibition activities of the compounds were determined using the stopped\u2010flow instrument. The synthesized peptide\u2013dihydroquinolinone conjugates <jats:bold>2<\/jats:bold>, <jats:bold>3<\/jats:bold>, <jats:bold>6<\/jats:bold>, <jats:bold>10<\/jats:bold>, <jats:bold>13<\/jats:bold>, and <jats:bold>15<\/jats:bold> showed inhibition against the hCA II enzyme in the range of 15.7\u201365.7\u2009\u00b5M. However, none of the compounds showed inhibition of hCA I at a concentration of 100\u2009\u00b5M. The antioxidant activities of the compounds were also examined using the DPPH (2,2\u2010diphenyl\u20101\u2010picrylhydrazyl) radical scavenging method at concentrations of 12.5\u2013125\u2009\u00b5g\/ml, but when compared with the standard antioxidant compounds \u03b1\u2010tocopherol and butylated hydroxyanisole (BHA), weak antioxidant activities were detected. The cytotoxic effects of four compounds against the A549 and BEAS\u20102B cell lines were also investigated. Among the compounds studied, compound <jats:bold>7<\/jats:bold> was found to be most effective, with the IC<jats:sub>50<\/jats:sub> values on the A549 cells for 48 and 72\u2009h being 26.87 and 9.979\u2009\u00b5g\/ml, respectively, and the IC<jats:sub>50<\/jats:sub> values on the BEAS\u20102B cells being &gt;100\u2009\u00b5g\/ml. None of the tested compounds showed antimicrobial activity in the concentration range (800\u20131.56\u2009\u00b5g\/ml) studied.<\/jats:p>","DOI":"10.1002\/ardp.202100122","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T11:45:19Z","timestamp":1627386319000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Synthesis of new 7\u2010amino\u20103,4\u2010dihydroquinolin\u20102(1<i>H<\/i>)\u2010one\u2010peptide derivatives and their carbonic anhydrase enzyme inhibition, antioxidant, and cytotoxic activities"],"prefix":"10.1002","volume":"354","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7180-9486","authenticated-orcid":false,"given":"Hasan","family":"K\u00fc\u00e7\u00fckbay","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Arts and Sciences \u0130n\u00f6n\u00fc University  Malatya 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