{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:28:56Z","timestamp":1792056536000,"version":"4.4.0"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009873","name":"Regione Autonoma della Sardegna","doi-asserted-by":"publisher","award":["RASSR17032"],"award-info":[{"award-number":["RASSR17032"]}],"id":[{"id":"10.13039\/501100009873","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The bioactive components of\n                    <jats:italic>Garcinia indica<\/jats:italic>\n                    , garcinol (camboginol), and isogarcinol (cambogin), are suitable drug candidates for the treatment of various human diseases. HIV\u20101\u2010RNase H assay was used to study the RNase H inhibition by garcinol and isogarcinol. Docking of garcinol into the active site of the enzyme was carried out to rationalize the difference in activities between the two compounds. Garcinol showed higher HIV\u20101\u2010RNase H inhibition than the known inhibitor RDS1759 and retained full potency against the RNase H of a drug\u2010resistant HIV\u20101 reverse transcriptase form. Isogarcinol was distinctly less active than garcinol, indicating the importance of the enolizable \u03b2\u2010diketone moiety of garcinol for anti\u2010RNase H activity. Docking calculations confirmed these findings and suggested this moiety to be involved in the chelation of metal ions of the active site. On the basis of its HIV\u20101 reverse transcriptase\u2010associated RNase H inhibitory activity, garcinol is worth being further explored concerning its potential as a cost\u2010effective treatment for HIV patients.\n                  <\/jats:p>","DOI":"10.1002\/ardp.202100123","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T02:54:55Z","timestamp":1621392895000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Garcinol from\n                    <i>Garcinia indica<\/i>\n                    inhibits HIV\u20101 reverse transcriptase\u2010associated ribonuclease H"],"prefix":"10.1002","volume":"354","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6630-8636","authenticated-orcid":false,"given":"Angela","family":"Corona","sequence":"first","affiliation":[{"name":"Laboratorio di Virologia Molecolare, Dipartimento di Scienze della Vita e Dell'Ambiente Universit\u00e1 degli Studi di Cagliari  Monserrato Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Seibt","sequence":"additional","affiliation":[{"name":"Organic Chemistry Laboratory University of Bayreuth  Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Schaller","sequence":"additional","affiliation":[{"name":"In Silico Toxicology and Structural Bioinformatics, Institute of Physiology Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Schobert","sequence":"additional","affiliation":[{"name":"Organic Chemistry Laboratory University of Bayreuth  Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3760-580X","authenticated-orcid":false,"given":"Andrea","family":"Volkamer","sequence":"additional","affiliation":[{"name":"In Silico Toxicology and Structural Bioinformatics, Institute of Physiology Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7305-346X","authenticated-orcid":false,"given":"Bernhard","family":"Biersack","sequence":"additional","affiliation":[{"name":"Organic Chemistry Laboratory University of Bayreuth  Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4849-0980","authenticated-orcid":false,"given":"Enzo","family":"Tramontano","sequence":"additional","affiliation":[{"name":"Laboratorio di Virologia Molecolare, Dipartimento di Scienze della Vita e Dell'Ambiente Universit\u00e1 degli Studi di Cagliari  Monserrato Italy"},{"name":"Istituto di Ricerca Genetica e Biomedica Consiglio Nazionale delle Ricerche (CNR)  Monserrato Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.367.6478.611"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00375-19"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.01.007"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix430"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30702-8"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00061-07"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001574"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R112.389056"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601076"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja411408x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2019.104613"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/2049-632X.12051"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-015-4652-0"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195168"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw060"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/v12070729"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/np040106y"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.4103\/1995-7645.250337"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1142\/7150"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21050559"},{"key":"e_1_2_7_22_1","first-page":"113896","volume":"270","author":"Wang Z.","year":"2021","journal-title":"J. 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