{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T01:32:47Z","timestamp":1768872767843,"version":"3.49.0"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006261","name":"Taif University","doi-asserted-by":"publisher","award":["TURSP\u20102020\/56"],"award-info":[{"award-number":["TURSP\u20102020\/56"]}],"id":[{"id":"10.13039\/501100006261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A gradient elution high\u2010performance liquid chromatographic method with a diode array detector is introduced for the first time for the simultaneous estimation of three drugs, namely, oxytetracycline hydrochloride (OXT), lidocaine (LDC), and bromhexine hydrochloride (BRH), in a veterinary formulation (OxyClear\u00ae solution) that contains many interfering additives. The method used a C\u20108 column. The chromatographic eluting solution included acidified water (0.1% trifluoroacetic acid in water) and acetonitrile at a 1\u2010ml\/min flow rate and 254\u2009nm as a nominated detection wavelength. The chromatographic process was assessed in terms of linearity, precision, accuracy, LOD, and LOQ. OXT, LDC, and BRH were linear in the range of 1\u201360, 5\u2013100, and 1\u201360\u2009\u03bcg\/ml, respectively. The three drugs were determined successfully without the interference of three excipients having UV absorbances. Furthermore, the purities of the peaks of the three drugs were confirmed by comparing the UV spectra of investigated peaks to the UV reference spectra in Clarke's Analysis of Drugs and Poisons. The greenness value of the method was 0.69 with a faint green\u2010colored pictogram using the AGREE tool. These merits recommend the application of the planned method in QC laboratories for purity testing and concentration assays for the pure drugs and commercial formulations.<\/jats:p>","DOI":"10.1002\/ardp.202100131","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T05:38:49Z","timestamp":1623821929000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Simultaneous analysis of oxytetracycline hydrochloride, lidocaine, and bromhexine hydrochloride in the presence of many interfering excipients"],"prefix":"10.1002","volume":"354","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4674-6516","authenticated-orcid":false,"given":"Mohammed","family":"Gamal","sequence":"first","affiliation":[{"name":"Pharmaceutical Chemistry Department, Faculty of Pharmacy Jouf University Sakaka Al Jouf Saudi Arabia"},{"name":"Pharmaceutical Analytical Chemistry Department Beni\u2010Suef University Beni\u2010Suef Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim A.","family":"Naguib","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Taif University Taif Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rehab M.","family":"Abdelfatah","sequence":"additional","affiliation":[{"name":"Pharmaceutical Analytical Chemistry Department Beni\u2010Suef University Beni\u2010Suef Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac025988p"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/rtph.2000.1421"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-019-0696-4"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/dddt.s291229"},{"key":"e_1_2_8_6_1","first-page":"83","volume":"4","author":"Ali Q.","year":"2019","journal-title":"PSM Microbiol."},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0an00076k"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2019.104258"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2013.07.015"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/bmaa065"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/bio.3648"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.32383\/appdr\/122147"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0ay02169e"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.0c01887"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.9734\/irjpac\/2018\/44345"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.5539\/ijc.v9n4p49"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2020.118743"},{"key":"e_1_2_8_18_1","first-page":"610","volume":"4","author":"Karthik Kumar B.","year":"2012","journal-title":"Int. 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