{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:18:20Z","timestamp":1787505500557,"version":"build-2736575974"},"reference-count":66,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T00:00:00Z","timestamp":1623024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In this study, 23 different imidazole derivatives were synthesized, and the inhibitory properties of these derivatives against carbonic anhydrase I and II isoenzymes were investigated for the first time. The inhibition concentrations of the imidazole derivatives were found to be in the range of 2.89\u2013115.5\u2009nM. Docking studies examined the binding properties of the imidazole derivatives, and the structure\u2013activity relationship is discussed. Theoretical calculations showed that the binding mode of the imidazole ring was non\u2010zinc binding.<\/jats:p>","DOI":"10.1002\/ardp.202100188","type":"journal-article","created":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T22:02:32Z","timestamp":1623103352000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A novel class for carbonic anhydrases inhibitors and evaluation of their non\u2010zinc binding"],"prefix":"10.1002","volume":"354","author":[{"given":"Burak","family":"Kuzu","sequence":"first","affiliation":[{"name":"Pharmaceutical Chemistry Section Van Y\u00fcz\u00fcnc\u00fc Yil University Van Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meltem","family":"Tan","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry Section Van Y\u00fcz\u00fcnc\u00fc Yil University Van Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lhami","family":"G\u00fcl\u00e7in","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences Atat\u00fcrk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5990-6275","authenticated-orcid":false,"given":"Nurettin","family":"Menges","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry Section Van Y\u00fcz\u00fcnc\u00fc Yil University Van Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2007.08.037"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2014.12.054"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm031057"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.104171"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm050483n"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm0612057"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201800209"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2004.12.052"},{"key":"e_1_2_8_10_1","unstructured":"\u00a0Eds: C. T. Supuran A. Scozzafava J. Conway Vol. 1 CRC Press2004."},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(03)00091-X"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2004.12.053"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.103468"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M308984200"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.06.055"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2013.782394"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2015.1067685"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj0430525"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2011.12.069"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm901287j"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm501573b"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja809683v"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm901287j"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm901524f"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2020.1788009"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm301625s"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2015.02.023"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2017.1316720"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2020.115496"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b01720"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm1003667"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00087a086"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.01.077"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2008.06.013"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2008.09.028"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2018.1512597"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CC07320G"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112875"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC05172A"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2018.1481404"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2014.04.121"},{"key":"e_1_2_8_42_1","first-page":"499","volume":"16","author":"Ul\u2010Hassan M.","year":"2001","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/07328303.2015.1009090"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comptc.2017.08.034"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comptc.2020.112911"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.2015.1066675"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.8b00076"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2015.02.027"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10091307"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo10100412"},{"key":"e_1_2_8_51_1","first-page":"2877","volume":"9","author":"Pastorek J.","year":"1994","journal-title":"Oncogene"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.13.7608"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.200300840"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11164-012-0665-z"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2011.03.044"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2013.06.040"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm800512z"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2007.01.074"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/hc.21412"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.01.044"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotochem.2019.111874"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlumin.2017.08.057"},{"key":"e_1_2_8_63_1","volume-title":"Gaussian 09, Revision D.01","author":"Frisch M. J.","year":"2009"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21256"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comptc.2015.06.031"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm4001117"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201600183"}],"container-title":["Archiv der Pharmazie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ardp.202100188","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ardp.202100188","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ardp.202100188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T21:32:40Z","timestamp":1692221560000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ardp.202100188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,7]]},"references-count":66,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1002\/ardp.202100188"],"URL":"https:\/\/doi.org\/10.1002\/ardp.202100188","archive":["Portico"],"relation":{},"ISSN":["0365-6233","1521-4184"],"issn-type":[{"value":"0365-6233","type":"print"},{"value":"1521-4184","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,7]]},"assertion":[{"value":"2021-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2100188"}}