{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:56:03Z","timestamp":1791896163729,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Human carbonic anhydrase (hCA) isoenzymes are zinc ion\u2010containing, widespread metalloenzymes and they classically play a role in pH homeostasis maintenance. CA inhibitors suppress the CA activity and their usage has been clinically established as antiglaucoma agents, antiepileptics, diuretics, and in some other disorders. Alzheimer's disease (AD) is a slowly progressive neurodegenerative disorder and a fatal disease of the brain. An advanced method to cure AD includes the strategy to design acetylcholinesterase (AChE) inhibitors. A novel series of pyrrole\u20103\u2010one derivatives containing sulfa drugs (\n                    <jats:bold>5a\u2013i<\/jats:bold>\n                    ) were determined to be highly potent inhibitors for AChE and hCA I and hCA II (inhibitory constant [\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>i<\/jats:sub>\n                    ] values are in the range of 6.50\u2009\u00b1\u20091.02\u201337.46\u2009\u00b1\u20094.12\u2009nM, 1.20\u2009\u00b1\u20090.19\u201344.21\u2009\u00b1\u20091.09\u2009nM, and 8.93\u2009\u00b1\u20091.58\u201346.86\u2009\u00b1\u20098.41\u2009nM for AChE, hCA I, and hCA II, respectively). The designed compounds often show a more effective inhibition than the chemicals used as the standard. Among these compounds,\n                    <jats:bold>5f<\/jats:bold>\n                    was the most effective compound against hCA I, and compound\n                    <jats:bold>5e<\/jats:bold>\n                    was the most effective compound against hCA II. It was determined that compound\n                    <jats:bold>5c<\/jats:bold>\n                    was the most effective inhibitor for AChE.\n                  <\/jats:p>","DOI":"10.1002\/ardp.202100242","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T18:18:07Z","timestamp":1633630687000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":275,"title":["Discovery of sulfadrug\u2013pyrrole conjugates as carbonic anhydrase and acetylcholinesterase inhibitors"],"prefix":"10.1002","volume":"355","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9262-7940","authenticated-orcid":false,"given":"Mehmet","family":"G\u00fcm\u00fc\u015f","sequence":"first","affiliation":[{"name":"Department of Occupational Health and Safety, Akdagmadeni Health College Yozgat Bozok University Yozgat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0006-2634","authenticated-orcid":false,"given":"\u015eemsi N.","family":"Babacan","sequence":"additional","affiliation":[{"name":"Department of Occupational Health and Safety, Akdagmadeni Health College Yozgat Bozok University Yozgat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3216-1098","authenticated-orcid":false,"given":"Yeliz","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, Nihat Delibalta Gole Vocational High School Ardahan University Ardahan Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8836-8667","authenticated-orcid":false,"given":"Yusuf","family":"Sert","sequence":"additional","affiliation":[{"name":"Department of Physics, Faculty of Art &amp; Sciences Yozgat Bozok University Yozgat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7873-159X","authenticated-orcid":false,"given":"\u0130rfan","family":"Koca","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Art &amp; Sciences Yozgat Bozok University Yozgat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5993-1668","authenticated-orcid":false,"given":"\u0130lhami","family":"G\u00fcl\u00e7in","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Atat\u00fcrk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2019.1623265"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.12.121"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.103969"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.104554"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.103884"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.103762"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/cryst10030171"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202000282"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3906\/kim-2004-36"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557520666200103100521"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202000243"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2019.11.003"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.103627"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.10025"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiolchem.2021.107565"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202000471"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201300273"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201600183"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2018.12.028"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2014.08.005"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2016.1198900"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.08.002"},{"key":"e_1_2_8_24_1","first-page":"135","volume":"5","author":"Koca \u0130.","year":"2012","journal-title":"Org. 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