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Eleven novel compounds were prepared, characterized by nuclear magnetic resonance experiments and screened for their antimicrobial activity against five bacterial species (<jats:italic>Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa<\/jats:italic>, and methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> [MRSA]) and two fungi (<jats:italic>Candida albicans<\/jats:italic> and <jats:italic>Cryptococcus neoformans<\/jats:italic>). The complexes showed similar or enhanced activities against MRSA in comparison to the corresponding ligands and, additionally, promising antifungal activities against <jats:italic>C. neoformans<\/jats:italic>. The most active compounds <jats:bold>3c<\/jats:bold> and <jats:bold>3h<\/jats:bold> showed remarkable activities against MRSA (minimum inhibitory activity [MIC] values of 32 and 4\u2009\u03bcg\/ml, respectively) and <jats:italic>C. neoformans<\/jats:italic> (MIC values of 8 and 16\u2009\u03bcg\/ml, respectively), accompanied by no human cell toxicity and hemolytic activity within the tested concentration range. The results demonstrate that appropriately functionalized tetramic acids attached with lipophilic alkanoyl chain and\u00a0after complexation with cadmium(II) ions may act as valuable lead compounds for further investigations toward\u00a0the development of novel antibacterial and\/or antifungal agents.<\/jats:p>","DOI":"10.1002\/ardp.202100305","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:23:45Z","timestamp":1632788625000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Synthesis and preliminary biological evaluation of antibacterial and antifungal 5\u2010arylidene tetramic acid\u2010cadmium(II) complexes"],"prefix":"10.1002","volume":"354","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0059-952X","authenticated-orcid":false,"given":"Dimitris","family":"Matiadis","sequence":"first","affiliation":[{"name":"Laboratory of Organic Chemistry, School of Chemical Engineering, National Technical University of Athens Zografou Campus Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Stefanou","sequence":"additional","affiliation":[{"name":"Laboratory of Organic Chemistry, School of Chemical Engineering, National Technical University of Athens Zografou Campus Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Tsironis","sequence":"additional","affiliation":[{"name":"Laboratory of Organic Chemistry, School of Chemical Engineering, National Technical University of Athens Zografou Campus Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angeliki","family":"Panagiotopoulou","sequence":"additional","affiliation":[{"name":"Institute of Biosciences and Applications National Center for Scientific Research \u201cDemokritos\u201d Ag. 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