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The synthesized compounds were found to show nanomolar affinity toward relevant isoforms of human carbonic anhydrase such as hCA I, II, IV, VII, IX, and XII. The divalent derivative <jats:bold>10d<\/jats:bold> showed a particularly high inhibitory activity against all hCA isoforms when compared with acetazolamide, and showed potent multivalent effects, better than reported previously for divalent CA inhibitors.<\/jats:p>","DOI":"10.1002\/ardp.202100405","type":"journal-article","created":{"date-parts":[[2021,12,4]],"date-time":"2021-12-04T07:42:55Z","timestamp":1638603775000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["1,5\u2010Benzodiazepines as a platform for the design of carbonic anhydrase inhibitors"],"prefix":"10.1002","volume":"355","author":[{"given":"Chiraz","family":"Ismail","sequence":"first","affiliation":[{"name":"Laboratory of Environmental Chemistry and Clean Processes\/LR21ES04 University of Monastir, Departement of Chemistry Monastir Tunisia"},{"name":"IBMM University of Montpellier, CNRS, ENSCM Montpellier 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