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These compounds were tested for their inhibitory activities on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and the human carbonic anhydrase isoenzymes I and II (hCA I and II). All synthesized molecules indicated significant inhibition effects with IC\n                    <jats:sub>50<\/jats:sub>\n                    values ranging from 14.15 to 107.62\u2009nM against these enzymes. Compound\n                    <jats:bold>2d<\/jats:bold>\n                    showed the most potent inhibitory activity among the tested molecules toward\u00a0AChE and BChE (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u200915.07 and 14.15\u2009nM) compared to the standard drug neostigmine. We determined that the IC\n                    <jats:sub>50<\/jats:sub>\n                    values of the tested molecules ranged between 16.86 and 57.96\u2009nM for hCA I and 15.24\u201346.21\u2009nM for hCA II. As a consequence, we may say that some of the Schiff base derivatives may be used as potential drug candidates in later studies.\n                  <\/jats:p>","DOI":"10.1002\/ardp.202100430","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T04:06:24Z","timestamp":1641528384000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Synthesis, characterization, and biological evaluation of some novel Schiff bases as potential metabolic enzyme inhibitors"],"prefix":"10.1002","volume":"355","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0401-7419","authenticated-orcid":false,"given":"Re\u015fit","family":"\u00c7akmak","sequence":"first","affiliation":[{"name":"Medical Laboratory Techniques Program, Vocational School of Health Services Batman University Batman 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