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Trichomoniasis is the most common nonviral sexually transmitted infection affecting more than 270 million people around the world. In our research group, we focussed on developing a selective and more effective drug against<jats:italic>Trichomonas vaginalis<\/jats:italic>, and we previously reported on a compound, called<jats:bold>A4<\/jats:bold>, which had a trichomonacidal effect. Later, we determined another compound, called<jats:bold>D4<\/jats:bold>, which also had a trichomonacidal effect together with favorable toxicity results. Both<jats:bold>A4<\/jats:bold>and<jats:bold>D4<\/jats:bold>are directed at the enzyme triosephosphate isomerase. Thus, we made combinations between the two compounds, in which we determined a synergistic effect against<jats:italic>T. vaginalis<\/jats:italic>, determining the IC<jats:sub>50<\/jats:sub>and the toxicity of the best relationship to obtain the trichomonacidal effect. With these results, we can propose a combination of compounds that represents a promising alternative for the development of a new therapeutic strategy against trichomoniasis.<\/jats:p>","DOI":"10.1002\/ardp.202200046","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T08:22:26Z","timestamp":1648196546000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Synergistic effect of compounds directed to triosephosphate isomerase, a combination to develop drug against trichomoniasis"],"prefix":"10.1002","volume":"355","author":[{"given":"Claudia G.","family":"Ben\u00edtez\u2010Cardoza","sequence":"first","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n Bioqu\u00edmica ENMyH\u2010Instituto Polit\u00e9cnico Nacional Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis G.","family":"Brieba","sequence":"additional","affiliation":[{"name":"Laboratorio Nacional de Gen\u00f3mica para la Biodiversidad Centro de Investigaci\u00f3n y de Estudios Avanzados del IPN Guanajuato M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossana","family":"Arroyo","sequence":"additional","affiliation":[{"name":"Departamento de Infect\u00f3mica y Patog\u00e9nesis Molecular Centro de Investigaci\u00f3n y de Estudios Avanzados del IPN Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturo","family":"Rojo\u2010Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Naturales Universidad Aut\u00f3noma Metropolitana Cuajimalpa Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8169-3715","authenticated-orcid":false,"given":"Jos\u00e9 L.","family":"Vique\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Mexicali Universidad Aut\u00f3noma de Baja California Mexicali Baja California M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2015.01.004"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001432-200002000-00007"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000128"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.5578\/mb.30140"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1806.111590"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1071\/SH09011"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2021.111413"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202000263"},{"key":"e_1_2_8_10_1","unstructured":"C. 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