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Based on previously identified chemotypes, we designed and synthesized new analogs that were screened toward the \u03b1, \u03b2, and \u03b3 classes encoded in <jats:italic>Vibrio cholerae<\/jats:italic> (Vch). The <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> values measured in the stopped\u2010flow hydrase assay revealed that very simple structural modifications might induce a relevant impact on the inhibitory effects as well as the selectivity profile over ubiquitous human isozymes (hCA I\/II). Unfortunately, the best active VchCA inhibitors demonstrated a dramatic loss of hCA II selectivity when compared to previously reported compounds. Among the new series of sulfonamides, several molecules proved to be about sevenfold more potent against VchCA\u03b3 than the reference compound acetazolamide, thus furnishing new insights for further development of inhibitors targeting CAs expressed in bacteria.<\/jats:p>","DOI":"10.1002\/ardp.202200070","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T04:04:12Z","timestamp":1656043452000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Synthesis and biological evaluation of sulfonamide\u2010based compounds as inhibitors of carbonic anhydrase from <i>Vibrio cholerae<\/i>"],"prefix":"10.1002","volume":"355","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2209-957X","authenticated-orcid":false,"given":"Francesca","family":"Mancuso","sequence":"first","affiliation":[{"name":"CHIBIOFARAM Department University of Messina  Messina 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