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In addition, CA enzyme inhibitory activities are known in groups such as sulfonamide and methylsulfonyl. For this purpose, in this study, a series of 23 new dithiocarbamate\u2010methylsulfonyl derivatives were synthesized and their CA enzyme inhibitory activities were investigated. The inhibition potentials of the obtained compounds against the human CA I and CA II enzymes were investigated by the in vitro enzyme isolation method. It is seen that the compounds show activity at the nanomolar level. Molecular docking studies of the compounds were carried out by in silico methods. The poses of compounds <jats:bold>2a<\/jats:bold>, <jats:bold>2e<\/jats:bold>, <jats:bold>2o<\/jats:bold>, and <jats:bold>2t<\/jats:bold> are presented.<\/jats:p>","DOI":"10.1002\/ardp.202200132","type":"journal-article","created":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T11:43:13Z","timestamp":1651578193000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Design, synthesis, and biological activity of novel dithiocarbamate\u2010methylsulfonyl hybrids as carbonic anhydrase inhibitors"],"prefix":"10.1002","volume":"355","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0499-436X","authenticated-orcid":false,"given":"Derya","family":"Osmaniye","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Anadolu University  Eski\u015fehir Turkey"},{"name":"Central Analysis Laboratory, Faculty of Pharmacy Anadolu University  Eski\u015fehir 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