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On the other hand, 4\u2010[4\u2010(piperidin\u20101\u2010ylsulfonyl)phenyl]\u20101\u2010[4\u2010(4\u2010nitrophenoxy)benzylidene]thiosemicarbazide (<jats:bold>2b<\/jats:bold>) was identified as a nonselective COX inhibitor (COX\u20101 IC<jats:sub>50<\/jats:sub>\u2009=\u200913.44\u2009\u00b1\u20090.65\u2009\u00b5M, COX\u20102 IC<jats:sub>50<\/jats:sub>\u2009=\u200912.60\u2009\u00b1\u20090.78\u2009\u00b5M). Based on molecular docking studies, the diaryl ether and the TSC groups serve as crucial moieties for interactions with pivotal amino acid residues in the active sites of COXs. According to MTT test, compounds <jats:bold>2b<\/jats:bold> and <jats:bold>2c<\/jats:bold> showed low cytotoxic activity toward NIH\/3T3 cells. Their in vivo anti\u2010inflammatory and antioxidant potencies were also assessed using the lipopolysaccharide\u2010induced sepsis model. Compounds <jats:bold>2b<\/jats:bold> and <jats:bold>2c<\/jats:bold> diminished high\u2010sensitivity C\u2010reactive protein, myeloperoxidase, nitric oxide, and malondialdehyde levels. Both compounds also caused a significant decrease in aspartate aminotransferase levels as well as alanine aminotransferase levels. In silico pharmacokinetic studies suggest that compounds <jats:bold>2b<\/jats:bold> and <jats:bold>2c<\/jats:bold> possess favorable drug\u2010likeness and oral bioavailability. It can be concluded that these compounds may act as orally bioavailable anti\u2010inflammatory and antioxidant agents.<\/jats:p>","DOI":"10.1002\/ardp.202200136","type":"journal-article","created":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T03:30:17Z","timestamp":1653363017000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A new series of thiosemicarbazone\u2010based anti\u2010inflammatory agents exerting their action through cyclooxygenase inhibition"],"prefix":"10.1002","volume":"355","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8159-663X","authenticated-orcid":false,"given":"Mehlika D.","family":"Alt\u0131ntop","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Anadolu University Eski\u015fehir 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