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The designed compounds inhibited hCA IX in a moderate nanomolar to submicromolar range. The hCA XII was inhibited in a low to moderate nanomolar range. Compound <jats:bold>6o<\/jats:bold> exhibited the best inhibition of hCA XII with a <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> value of 91.1\u2009nM. The hydrolyzed form of compound <jats:bold>6o<\/jats:bold> also exhibited favorable interactions as well as good docking scores with both the isoforms. Hence, this compound can be taken as a template for the design of selective and potent hCA XII inhibitors.<\/jats:p>","DOI":"10.1002\/ardp.202200232","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T18:55:16Z","timestamp":1663613716000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Synthesis and biological evaluation of coumarin\u2010thiazole hybrids as selective carbonic anhydrase IX and XII inhibitors"],"prefix":"10.1002","volume":"355","author":[{"given":"Pavitra S.","family":"Thacker","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry National Institute of Pharmaceutical Education and Research (NIPER) Balanagar Hyderabad India"},{"name":"Department of Pharmaceutical Chemistry, L.J. Institute of Pharmacy L.J. 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