{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:06:11Z","timestamp":1768262771274,"version":"3.49.0"},"reference-count":86,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T00:00:00Z","timestamp":1660867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007111","name":"Bartin \u00dcniversitesi","doi-asserted-by":"publisher","award":["2020\u2010FEN\u2010B\u2010005"],"award-info":[{"award-number":["2020\u2010FEN\u2010B\u2010005"]}],"id":[{"id":"10.13039\/501100007111","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Five 4\u2010hydroxyphenylethyl substituted pyridine enhanced, precatalyst, preparation, stabilization, and initiation\u2010Pd\u2010N\u2010heterocyclic carbene\u00a0(PEPPSI\u2010Pd\u2010NHC) complexes are synthesized in a straightforward way. All PEPPSI\u2010Pd\u2010NHC complexes were prepared by mixing 4\u2010hydroxyphenylethyl substituted NHC precursors, palladium chloride, potassium carbonate, and potassium bromide in pyridine. All complexes were screened for human carbonic anhydrase I (hCA I)\u00a0and hCA II, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and \u03b1\u2010glucosidase (\u03b1\u2010Glu) inhibitory activities. The ChE inhibitory activities of the new PEPPSI\u2010Pd\u2010NHC complexes bearing the 4\u2010hydroxyphenylethyl group (<jats:bold>1a\u2013e<\/jats:bold>) against \u03b1\u2010Glu, AChE, and BChE were determined by the Tao and Ellman methods. The results indicated that all the synthetic complexes exhibited potent inhibitory activities against all targets as compared to the standard inhibitors, revealed by IC<jats:sub>50<\/jats:sub> values. The <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> values of the new PEPPSI\u2010Pd\u2010NHC complexes <jats:bold>1a\u2013e<\/jats:bold> for hCA I, hCA II, AChE, BChE, and \u03b1\u2010Glu were obtained in the ranges of 18.98\u201332.65, 22.95\u201338.13, 3.67\u201311.65, 4.09\u20139.36, 186.92\u2013287.45\u2009\u00b5M, respectively. Among the synthesized complexes, the most potent complexes were <jats:bold>1c<\/jats:bold> toward hCA I and II with <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> values 18.98 and 22.95\u2009\u00b5M, and <jats:bold>1d<\/jats:bold> toward AChE and BChE with <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub>\u2009=\u20093.67 and 4.09\u2009\u00b5M, respectively.<\/jats:p>","DOI":"10.1002\/ardp.202200276","type":"journal-article","created":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T03:19:10Z","timestamp":1660965550000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["New PEPPSI\u2010Pd\u2010NHC complexes bearing 4\u2010hydroxyphenylethyl group: Synthesis, characterization, molecular docking, and bioactivity properties"],"prefix":"10.1002","volume":"355","author":[{"given":"Ayten","family":"Beh\u00e7et","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science and Arts Inonu University  Malatya T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0074-9930","authenticated-orcid":false,"given":"Parham","family":"Taslimi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Faculty of Science Bartin University  Bartin T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yetkin","family":"G\u00f6k","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science and Arts Inonu University  Malatya T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayd\u0131n","family":"Akta\u015f","sequence":"additional","affiliation":[{"name":"Vocational School of Health Service Inonu University Malatya T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tugba","family":"Taskin\u2010Tok","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Arts and Sciences Gaziantep University Gaziantep T\u00fcrkiye"},{"name":"Department of Bioinformatics and Computational Biology, Institute of Health Sciences Gaziantep University  Gaziantep T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130lhami","family":"G\u00fcl\u00e7in","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Atat\u00fcrk University  Erzurum T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00001a054"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.4068"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.201802519"},{"key":"e_1_2_7_5_1","first-page":"1664","volume":"38","author":"Akta\u015f A.","year":"2019","journal-title":"Chin. J. Struct. Chem."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2004.05.013"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.196801412"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2017.12.019"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10562-017-2132-3"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13738-017-1216-8"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.201802046"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.201901033"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2019.127608"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2021.120747"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jorganchem.2019.06.019"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2019.118969"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1217359"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/catal10101190"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jorganchem.2019.01.003"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/C2CS35314H"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jorganchem.2017.03.037"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2016.05.001"},{"issue":"81","key":"e_1_2_7_23_1","first-page":"12238","volume":"56","author":"Scattolin T.","year":"2020","journal-title":"ChemComm"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jorganchem.2015.07.003"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201900187"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.103134"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00706-020-02687-2"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2020.129442"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.poly.2021.115060"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.104554"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2020.1792345"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.103468"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-020-07611-z"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.104171"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2020.1818623"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202100775"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2021.131470"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.105566"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202000958"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2021.127839"},{"key":"e_1_2_7_41_1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/978-1-4939-9752-7_10","volume-title":"Molegro Virtual Docker for Docking Docking Screens for Drug Discovery","author":"Bitencourt\u2010Ferreira G.","year":"2019"},{"key":"e_1_2_7_42_1","first-page":"47","volume":"4","author":"Kusumaningrum S.","year":"2014","journal-title":"J. Appl. Sci."},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.2174\/157340911795677602"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2018.05.077"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201900304"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2020.128210"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00706-019-2350-z"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22261"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2018.11.053"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2021.128449"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(92)90167-N"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm501573b"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201600047"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2015.1054820"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2012.670807"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201300349"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2014.07.009"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2018.09.013"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22009"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.201801019"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.02.013"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.02.008"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201800317"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.103017"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202000254"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.4199"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22006"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.01.044"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201800263"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2018.08.003"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2020.1790422"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00104"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)95800-X"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.5650\/jos.ess21106"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2020.129666"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(61)90145-9"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202000409"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22765"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.2761"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2021.103180"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.105032"},{"key":"e_1_2_7_82_1","unstructured":"Gaussian 09 Revision E.01 M. J.Frisch G. W.Trucks H. B.Schlegel G. E.Scuseria M. A.Robb J. R.Cheeseman G.Scalmani V.Barone B.Mennucci G. A.Petersson Gaussian Inc. Wallingford CT 2009."},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn750"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bti770"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2013.01.030"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.22146\/ijc.23568"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.05.010"}],"container-title":["Archiv der Pharmazie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ardp.202200276","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ardp.202200276","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ardp.202200276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T07:27:25Z","timestamp":1692689245000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ardp.202200276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,19]]},"references-count":86,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1002\/ardp.202200276"],"URL":"https:\/\/doi.org\/10.1002\/ardp.202200276","archive":["Portico"],"relation":{},"ISSN":["0365-6233","1521-4184"],"issn-type":[{"value":"0365-6233","type":"print"},{"value":"1521-4184","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,19]]},"assertion":[{"value":"2022-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2200276"}}