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Based on the analytical and spectral analyses, a linear geometry was proposed for all the Ag(I) complexes, except for one (with the furan moiety), which formed a distorted T\u2010shaped geometry. UV\u2010vis absorption studies on the interactions of calf thymus\u2010DNA (CT\u2010DNA) with the nine Ag(I) complexes pointed to an intercalative binding mode. With a binding constant<jats:italic>K<\/jats:italic><jats:sub>b<\/jats:sub>of 3.75\u2009\u00d7\u200910<jats:sup>5<\/jats:sup>M<jats:sup>\u22121<\/jats:sup>, the complex bearing a benzothiazole moiety (<jats:bold>1<\/jats:bold>) interacted stronger with CT\u2010DNA than the rest of the complexes. Fluorescence spectroscopic data revealed that the complexes had a modest binding affinity for BSA through static quenching. The complexes displayed good antioxidant properties, especially those with a benzothiazole moiety. Notable antibacterial activities against methicillin\u2010resistant<jats:italic>Staphylococcus aureus, Staphylococcus aureus<\/jats:italic>,<jats:italic>Salmonella typhimurium<\/jats:italic>,<jats:italic>Pseudomonas aeruginosa<\/jats:italic>,<jats:italic>Escherichia coli<\/jats:italic>, and<jats:italic>Klebsiella pneumoniae<\/jats:italic>were observed for complexes with the furan and thiophene moieties. The in vitro anticancer studies of selected complexes against three cancer cell lines showed that the complexes were more effective against the inhibition of the growth of cervical cancer cells relative to cisplatin.<\/jats:p>","DOI":"10.1002\/ardp.202200308","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T01:24:46Z","timestamp":1666056286000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Silver(I) pyridinyl complexes with benzothiazole, thiophene, and furan moieties: DNA\/protein\u2010binding, antibacterial, antioxidant, and anticancer studies"],"prefix":"10.1002","volume":"356","author":[{"given":"Adesola A.","family":"Adeleke","sequence":"first","affiliation":[{"name":"School of Chemistry and Physics University of Kwazulu\u2010Natal Westville South Africa"},{"name":"Department of Chemical Sciences Olabisi Onabanjo University Ago\u2010Iwoye Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Shahidul","family":"Islam","sequence":"additional","affiliation":[{"name":"Discipline of Biochemistry, School of Life Sciences University of Kwazulu\u2010Natal Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3003-6712","authenticated-orcid":false,"given":"Bernard","family":"Omondi","sequence":"additional","affiliation":[{"name":"School of Chemistry and Physics University of Kwazulu\u2010Natal Westville South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4314\/tjpr.v17i12.29"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","unstructured":"I.Benmahammed T.Douadi S.Issaadi M.Al\u2010Noaimi S.Chafaa J. Dispers Sci. 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