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Additionally, celecoxib demonstrated potent antitumor and chemopreventive effects in vitro, in vivo, and in patients. The mechanism of celecoxib's chemopreventive effect is still not fully identified, but it is assumed to be multifactorial. Celecoxib's anticancer activity has been described both as independent of and dependent on its COX\u20102 inhibitory activity. The current review summarizes the recent advances published between 2000 and 2022 on the structure\u2010based optimization of celecoxib to develop compounds with promising anticancer activity. The structure\u2013activity relationships of celecoxib analogs are discussed, which may be beneficial in the design and development of novel analogs as potent antiproliferative agents in the future.<\/jats:p>","DOI":"10.1002\/ardp.202200326","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T05:41:15Z","timestamp":1661233275000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Recent advances in the development of celecoxib analogs as anticancer agents: A review"],"prefix":"10.1002","volume":"355","author":[{"given":"Eman F.","family":"Abdelhaleem","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6091-829X","authenticated-orcid":false,"given":"Asmaa 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