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The structures of the compounds were identified by FT\u2010IR, <jats:sup>1<\/jats:sup>H NMR, and <jats:sup>13<\/jats:sup>C NMR spectroscopy, elemental analysis, and mass spectrometry. The crystal structure of <jats:bold>1b<\/jats:bold> was determined by the single\u2010crystal X\u2010ray diffraction method. The phthalimide\u2010tethered imidazolium salts exhibited inhibition abilities toward\u00a0acetylcholinesterase (AChE) and human carbonic anhydrases (hCAs) I and II, with <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> values in the range of 24.63\u2009\u00b1\u20093.45 to 305.51\u2009\u00b1\u200935.98\u2009nM for AChE, 33.56\u2009\u00b1\u20093.71 to 218.01\u2009\u00b1\u200925.21\u2009nM for hCA I and 17.75\u2009\u00b1\u20090.96 to 308.67\u2009\u00b1\u200913.73\u2009nM for hCA II. The results showed that the new imidazolium salts can play a key role in the treatment of Alzheimer's disease, epilepsy, glaucoma, and leukemia, which is related to their inhibition abilities of hCA I, hCA II, and AChE. Molecular docking and in silico absorption, distribution, metabolism, excretion and toxicity studies were used to look into how the imidazolium salts interacted with the specific protein targets. To better visualize and understand the binding positions and the influence of the imidazolium salts on hCA I, hCA II, and AChE conformations, each one was subjected to molecular docking simulations.<\/jats:p>","DOI":"10.1002\/ardp.202200348","type":"journal-article","created":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T18:39:55Z","timestamp":1664131195000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Phthalimide\u2010tethered imidazolium salts: Synthesis, characterization, enzyme inhibitory properties, and in silico studies"],"prefix":"10.1002","volume":"355","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5717-8788","authenticated-orcid":false,"given":"Murat","family":"Yi\u011fit","sequence":"first","affiliation":[{"name":"Department of Chemistry and Chemical Process Technologies, Vocational School of Technical Sciences Adiyaman University Ad\u0131yaman Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3216-1098","authenticated-orcid":false,"given":"Yeliz","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, Nihat Delibalta G\u00f6le Vocational High School Ardahan University Ardahan Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duygu","family":"Barut Celepci","sequence":"additional","affiliation":[{"name":"Department of Physics, Faculty of Science Dokuz Eyl\u00fcl University \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0064-8400","authenticated-orcid":false,"given":"Tu\u011fba","family":"Taskin\u2010Tok","sequence":"additional","affiliation":[{"name":"Department of Chemistry,\u00a0Faculty of Arts and Sciences Gaziantep University Gaziantep Turkey"},{"name":"Department of Bioinformatics and Computational Biology, Institute of Health Sciences Gaziantep University Gaziantep Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Ar\u0131n\u00e7","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science and Art Adiyaman University Ad\u0131yaman Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beyhan","family":"Yi\u011fit","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science and Art Adiyaman University Ad\u0131yaman Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhittin","family":"Ayg\u00fcn","sequence":"additional","affiliation":[{"name":"Department of Physics, Faculty of Science Dokuz Eyl\u00fcl University \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6325-0216","authenticated-orcid":false,"given":"\u0130smail","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science and Art \u0130n\u00f6n\u00fc University Malatya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130lhami","family":"G\u00fcl\u00e7in","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Atat\u00fcrk University Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,25]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Chapter 5\u2010Five\u2010Membered Heterocycles","author":"Ram V. 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