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Thus, the treatment regimen for this disorder is highly crucial at this time. Flavaglines are a natural class of cyclopentane benzofurans exhibiting various bioactivities like anticancer action. Despite the antiproliferative activity of flavaglines against diverse cancer cells, their roles and mechanism of action in chronic myeloid leukemia (CML) remain poorly understood. Thus, this study examines the antiproliferative effect of a newly synthesized flavagline derivative, 1\u2010chloracetylrocaglaol (A2074), on erythroleukemia K562 cells and the zebrafish xenograft model. The study revealed that A2074 could inhibit proliferation, promote apoptosis, and boost megakaryocyte differentiation of K562 cells. This flavagline downregulated c\u2010MYC and miR\u201017\u201092 cluster genes, targeting upregulation of the apoptotic protein Bcl\u20102\u2010like\u00a0protein\u00a011\u00a0(BIM). The work uncovered a critical role of the c\u2010MYC\u2010miR\u201017\u201092\u2010BIM axis in the growth and survival of CML cells.<\/jats:p>","DOI":"10.1002\/ardp.202200367","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T01:25:52Z","timestamp":1665451552000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthetic flavagline derivative 1\u2010chloroacetylrocaglaol promotes apoptosis in K562 erythroleukemia cells through miR\u201017\u201092 cluster genes"],"prefix":"10.1002","volume":"355","author":[{"given":"Xijun","family":"Wu","sequence":"first","affiliation":[{"name":"State Key Laboratory for Functions and Applications of Medicinal Plants, Department of Immunology, School of Pharmaceutical Sciences, The Affiliated Jinyang Hospital Guizhou Medical University Guiyang China"},{"name":"The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese 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