{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:13:04Z","timestamp":1790107984136,"version":"4.0.1"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T00:00:00Z","timestamp":1667174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Twenty novel 1,2,3\u2010triazole benzenesulfonamides featuring nitrile <jats:bold>8a\u2013g<\/jats:bold>, carbothioamide <jats:bold>9a\u2013f<\/jats:bold>, and <jats:italic>N<\/jats:italic>\u2032\u2010hydroxycarboximidamide <jats:bold>10a\u2013g<\/jats:bold> functionalities were designed and synthesized to improve potency and selectivity as carbonic anhydrase inhibitors (CAIs). The synthesized 1,2,3\u2010triazole compounds were tested in vitro as CAIs against four physiologically and pharmacologically relevant isoforms of human carbonic anhydrase (hCA I, II, IV, and IX). Compounds <jats:bold>8a\u2013g<\/jats:bold>, <jats:bold>9a\u2013f<\/jats:bold>, and <jats:bold>10a\u2013g<\/jats:bold> displayed variable inhibition constants ranging from 8.1\u2009nM to 3.22\u2009\u03bcM for hCA I, 4.7\u2009nM to 0.50\u2009\u03bcM for hCA II, 15.0\u2009nM to 3.7\u2009\u03bcM for hCA IV, and 29.6\u2009nM to 0.27\u2009\u03bcM for hCA IX. As per the inhibition data profile, compounds <jats:bold>9a\u2013e<\/jats:bold> exhibited strong efficacy for hCA IV, whereas the inhibition was found to be somewhat diminished in the case of hCA IX by nearly all the compounds. A computational protocol based on docking and MM\u2010GBSA was conducted to reveal the plausible interactions of the targeted sulfonamides within the hCA II and IX binding sites. The outcomes of appending various functionalities at the C\u20104 position of the 1,2,3\u2010triazole motif over the inhibition potential and selectivity of the designed sulfonamides were examined with a potential for the discovery of new isoform selective CAIs. The CAI and SAR data established the significance of the synthesized 1,2,3\u2010triazoles as building blocks for developing CAI drugs.<\/jats:p>","DOI":"10.1002\/ardp.202200391","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T02:55:53Z","timestamp":1667271353000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Benzenesulfonamides with trisubstituted triazole motif as selective carbonic anhydrase I, II, IV, and IX inhibitors"],"prefix":"10.1002","volume":"356","author":[{"given":"Vikas","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Chemistry Kurukshetra University  Kurukshetra India"},{"name":"Pt. Chiranji Lal Sharma Government College Karnal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Kumar","sequence":"additional","affiliation":[{"name":"Ch. 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