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Following the SRB assay, compounds were evaluated for their c\u2010Met kinase and COX\u20102 inhibitory potential. All compounds inhibited COX\u20102 with half\u2010maximal inhibitory concentration (IC<jats:sub>50<\/jats:sub>) &lt;10\u2009\u00b5M. Compounds <jats:bold>7h<\/jats:bold>, <jats:bold>7i<\/jats:bold>, <jats:bold>7j<\/jats:bold>, <jats:bold>8f<\/jats:bold>, and <jats:bold>8j<\/jats:bold> inhibited c\u2010Met with IC<jats:sub>50<\/jats:sub> &lt;10\u2009\u00b5M. Compound <jats:bold>7h<\/jats:bold> was evaluated for its long\u2010term antiproliferative and anti\u2010migratory effects by colony formation and wound healing assay. It exerted these effects in a concentration\u2010dependent manner. Compounds <jats:bold>7j<\/jats:bold> and <jats:bold>8j<\/jats:bold> were further evaluated for in vitro antiangiogenic effects. Compound <jats:bold>7j<\/jats:bold> exhibited moderate antiangiogenic effect while compound <jats:bold>8j<\/jats:bold> exhibited strong effect. Compounds <jats:bold>7h<\/jats:bold>, <jats:bold>7i<\/jats:bold>, <jats:bold>7j<\/jats:bold>, <jats:bold>8f<\/jats:bold>, and <jats:bold>8j<\/jats:bold> were evaluated for the serum protein binding, using the in vitro bovine serum albumin binding assay. The results indicated that the tested compounds bind to bovine serum albumin (BSA) and can be further explored by other studies.<\/jats:p>","DOI":"10.1002\/ardp.202200405","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T10:39:27Z","timestamp":1675852767000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Synthesis and biological evaluation of benzamide\u2010chalcone hybrids as potential c\u2010Met\u00a0kinase and COX\u20102 inhibitors"],"prefix":"10.1002","volume":"356","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2589-6336","authenticated-orcid":false,"given":"Heena","family":"Bhojwani","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry Principal K. M. 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