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Prompted by the scope, novel benzenesulfonamides containing the 1,2,3\u2010triazolylthiazolotriazole tail were synthesized and screened as inhibitors of hCA isoforms I, II, IV, and IX. The tumor\u2010associated isoform hCA IX was strongly inhibited by the sulfonamides reported here with <jats:italic>K<\/jats:italic><jats:sub>I<\/jats:sub> values ranging from 45\u2009nM to 1.882\u2009\u03bcM. Overall, nine compounds showed hCA IX inhibition with <jats:italic>K<\/jats:italic><jats:sub>I<\/jats:sub>\u2009&lt;\u2009250\u2009nM. The glaucoma\u2010associated isoform hCA II was moderately inhibited while the cytosolic isoform hCA I and membrane\u2010bound isoform hCA IV were weakly inhibited by the synthesized sulfonamides. Compound <jats:bold>6Ac<\/jats:bold> (<jats:italic>K<\/jats:italic><jats:sub>I<\/jats:sub>\u2009=\u20093.6\u2009nM) was found to be an almost three times more potent inhibitor of hCA II as compared to the standard drug acetazolamide (<jats:italic>K<\/jats:italic><jats:sub>I<\/jats:sub>\u2009=\u200912.1\u2009nM). The selective hCA IX inhibitors were further studied for their apoptotic efficacy in goat ovarian cells and showed better results as compared to the control. A comparative study of previously synthesized compounds and molecular docking study of representative compounds revealed some important generalizations that could prove beneficial in further investigations of isoform\u2010selective hCA inhibitors.<\/jats:p>","DOI":"10.1002\/ardp.202200439","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T03:15:40Z","timestamp":1667877340000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Tail approach synthesis of triazolylthiazolotriazole bearing benzenesulfonamides as carbonic anhydrase inhibitors capable of inducing apoptosis"],"prefix":"10.1002","volume":"356","author":[{"given":"Lalit","family":"Vats","sequence":"first","affiliation":[{"name":"Department of Chemistry Kurukshetra University  Kurukshetra Haryana India"},{"name":"Department of Chemistry Government College Bherian, Pehowa  Kurukshetra Haryana 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