{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:30:12Z","timestamp":1786977012286,"version":"build-2736575974"},"reference-count":96,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Currently, cancer is the most grieving threat to society. The cancer\u2010related death rate has had an ascending trend, despite the implementation of numerous treatment strategies or the discovery of an array of potent molecules against several pathways of cancer growth. The need of the hour is to prevent the multidrug resistance toll, and the current efforts have been bestowed upon a versatile small molecule scaffold, coumarin (benz[\u03b1]pyrone), a natural compound possessing interesting affinity toward\u00a0the cancer target human carbonic anhydrase (hCA), focusing on hCA I, II, IX, and XII. Along with coumarin, the age\u2010old known antibacterial drug sulfonamide, when conjugated at positions 3, 7, and 8 of coumarin either with a linker group or as a single entity, has been reported to enhance the affinity of coumarin toward\u00a0the overexpressed enzymes in tumor cell lines. The sulfonamides have been listed as obsolete drugs due to the severe side effects caused by them; however, their affinity toward\u00a0the hCA\u2010zinc\u2013binding core has attracted the attention of researchers. Hence, in the process of drug development, coumarin and sulfonamides have remained the choice of last resort. To unveil the synthetic strategy of coumarin\u2010sulfonamide conjugation, their rationale for inhibiting cancer cells\/enzymes, and their affinity toward\u00a0various types of carcinoma have been the sole goal of the researchers. This review specifically focuses on the mechanism of action and the structure\u2013activity relationship through synthetic strategies and the binding affinity of coumaryl\u2010sulfonamide conjugates with the anticancer targets possessing the highest enzyme affinity, since 2008.<\/jats:p>","DOI":"10.1002\/ardp.202200508","type":"journal-article","created":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T21:16:01Z","timestamp":1672607761000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Coumaryl\u2010sulfonamide moiety: Unraveling their synthetic strategy and specificity toward\u00a0\n                    <i>h<\/i>\n                    CA IX\/XII, facilitating anticancer drug development"],"prefix":"10.1002","volume":"356","author":[{"given":"Monalisa","family":"Mahapatra","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry, School of Pharmaceutical Sciences Siksha \u2018O\u2019 Anusandhan Deemed to be University  Bhubaneswar Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suman K.","family":"Mekap","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Life Sciences Centurion University of Technology and Management  R. Sitapur Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suvadeep","family":"Mal","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, School of Pharmaceutical Sciences Siksha \u2018O\u2019 Anusandhan Deemed to be University  Bhubaneswar Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyotirmaya","family":"Sahoo","sequence":"additional","affiliation":[{"name":"School of Pharmacy Arka Jain University  Jameshedpur Jharkand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeeb K.","family":"Sahoo","sequence":"additional","affiliation":[{"name":"Institute of Life Sciences  Bhubaneswar Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1210-2293","authenticated-orcid":false,"given":"Sudhir K.","family":"Paidesetty","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, School of Pharmaceutical Sciences Siksha \u2018O\u2019 Anusandhan Deemed to be University  Bhubaneswar Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.12.655"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30342-5"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-010-0990-0"},{"key":"e_1_2_10_6_1","unstructured":"World Health Organization.International Agency for Research on Cancer.https:\/\/gco.iarc.fr\/today\/home"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11706"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871520622666220304184525"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2022.2083502"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2022.2056734"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.04.014"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.01.070"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2467"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/ml500196t"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c00733"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2019.1701554"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2020.102922"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.164.3876.181"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2018.05.022"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S364746"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.03.069"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2018.05.015"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2021.130908"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2021.131824"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2015.04.036"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/1758835920925991"},{"key":"e_1_2_10_27_1","first-page":"3208","volume":"57","author":"Yoshimatsu K.","year":"1997","journal-title":"Cancer Res."},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002800050795"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.13040\/IJPSR.0975-8232.6(9).3713-25"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3816\/CCC.2008.n.006"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001813-200211000-00002"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2003.09.062"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1026282716250"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18040851"},{"key":"e_1_2_10_35_1","first-page":"745","volume":"23","author":"Xiang Y.","year":"2002","journal-title":"Acta Pharmacol. 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