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The human blood is slightly alkaline, which is essential for cell metabolism, normal physiology, and balanced immunity since all of these biological processes are pH\u2010dependent. Varieties of physiologic derangements occur when the blood pH is disrupted. Severe acute respiratory syndrome coronavirus\u20102 (SARS\u2010CoV\u20102) proliferates in acidic blood that magnifies the severity of COVID\u201019. On the other side, blood acidemia is linked to increased morbidity and mortality because of its complications on immunity, especially in the elderly and in critical diseases such as cancer, musculoskeletal degradation, renal, cardiac, and pulmonary disorders, which result in many pathological disorders such as osteomalacia, and disturbing the hematopoiesis. Additionally, acidemia of the blood facilitates viral infection and progression. Thus, correcting the acid\u2013base balance might be a crucial strategy for the treatment of COVID\u201019, which might be attributed to the distraction of the viral spike protein to its cognate receptor angiotensin\u2010converting enzyme 2 and\u00a0supporting the over\u2010taxed immunity.<\/jats:p>","DOI":"10.1002\/ardp.202200558","type":"journal-article","created":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T03:09:08Z","timestamp":1674529748000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Blood pH and COVID\u201019"],"prefix":"10.1002","volume":"356","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1077-2755","authenticated-orcid":false,"given":"Mahmoud Fahmi","family":"Elsebai","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4642-4864","authenticated-orcid":false,"given":"EL\u2010Sayed E.","family":"Habib","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Faculty of Pharmacy Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,23]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"161","volume":"86","author":"Hamilton P. 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