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Analog <jats:bold>11d<\/jats:bold> [L\u2010His(2\u2010adamantyl)\u2010L\u2010Trp\u2010L\u2010His(2\u2010phenyl)\u2010OMe] produced potency with an IC<jats:sub>50<\/jats:sub> of 3.02\u2009\u00b5g\/ml (MIC\u2009=\u20095.49\u2009\u00b5g\/ml). This peptide is noncytotoxic and nonhaemolytic at the MIC and displays synergistic effects with amphotericin B at subinhibitory concentration. Mechanistic investigation of <jats:bold>11d<\/jats:bold> using microscopic tools indicates cell wall and membrane disruption of <jats:italic>C. neoformans<\/jats:italic>, while flow cytometric analysis confirms cell death by apoptosis. This study indicates that <jats:bold>11d<\/jats:bold> exhibits antifungal potential and acts via the rapid onset of action.<\/jats:p>","DOI":"10.1002\/ardp.202200576","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T20:15:33Z","timestamp":1672690533000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Anticryptococcal activity and mechanistic studies of short amphipathic peptides"],"prefix":"10.1002","volume":"356","author":[{"given":"Shams","family":"Aaghaz","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry National Institute of Pharmaceutical Education and Research Nagar Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Komal","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry National Institute of Pharmaceutical Education and Research Nagar Punjab 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