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Subsequently, their anticholinesterease and antioxidant (ORAC) activities were tested. Among them, compound\n                    <jats:bold>3e<\/jats:bold>\n                    was the most potent acetylcholinesterase (AChE) inhibitor (AChE IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u20090.5\u2009\u03bcM, butyrylcholinesterase [BChE] IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u200914.7\u2009\u03bcM) and compound\n                    <jats:bold>9e<\/jats:bold>\n                    was the most potent BChE inhibitor (AChE IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u20093.13\u2009\u03bcM, BChE IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u20090.9\u2009\u03bcM). Kinetic experiments showed that both compounds were mixed\u2010type inhibitors. According to the anticholinesterease activity results, five compounds (\n                    <jats:bold>3e<\/jats:bold>\n                    ,\n                    <jats:bold>4e<\/jats:bold>\n                    ,\n                    <jats:bold>5e<\/jats:bold>\n                    ,\n                    <jats:bold>9d<\/jats:bold>\n                    , and\n                    <jats:bold>9e<\/jats:bold>\n                    ) were selected for further activity studies, all of which are dual cholinesterase inhibitors. Then, selected compounds were investigated in terms of their metal chelation activity. Moreover, their neuroprotective effects against H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2010induced damage in the PC12 cell line were evaluated at 10\u2009\u03bcM and the results showed that the neuroprotective effect of\n                    <jats:bold>3e<\/jats:bold>\n                    was 53% compared with the reference ferulic acid (77%). 3\u2010(4,5\u2010dimethylthiazol\u20102\u2010yl)\u20102,5\u2010diphenyltetrazolium bromide (MTT) results of selected compounds revealed that the compounds were noncytotoxic. Additionally,\n                    <jats:bold>3e<\/jats:bold>\n                    was more effective in reducing lipopolysaccharides\u2010induced interleukin\u20101\u03b2 (IL\u20101\u03b2), IL\u20106, tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), and nitric oxide (NO) production in the human monocyte derived from patient with acute monocytic leukemia cell line compared with other selected compounds. Finally, a molecular docking study was also performed.\n                  <\/jats:p>","DOI":"10.1002\/ardp.202300054","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T01:27:59Z","timestamp":1686101279000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Synthesis and evaluation of multitarget new 2\u2010aminothiazole derivatives as potential anti\u2010Alzheimer's agents"],"prefix":"10.1002","volume":"356","author":[{"given":"Merve","family":"Bardakkaya","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Gazi University Ankara Turkiye"},{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Biruni University \u0130stanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8737-829X","authenticated-orcid":false,"given":"Burcu","family":"Kilic","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Gazi University Ankara Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3844-6158","authenticated-orcid":false,"given":"Rahsan Il\u0131kc\u0131","family":"Sagkan","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Faculty of Medicine U\u015fak University U\u015fak Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2557-9616","authenticated-orcid":false,"given":"Fatma","family":"Aksakal","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Hacettepe University Ankara Turkiye"},{"name":"Department of Analytical Chemistry, Faculty of Pharmacy Kocaeli Health and Technology University Kocaeli Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8072-0259","authenticated-orcid":false,"given":"Shakila","family":"Shakila","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Gazi University Ankara Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8221-5579","authenticated-orcid":false,"given":"Deniz S.","family":"Dogruer","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Gazi University Ankara Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.disamonth.2010.06.001"},{"key":"e_1_2_7_3_1","first-page":"1","author":"World Alzheimer Report 2019: Attitudes to dementia","year":"2019","journal-title":"Alzheimer's Dis. 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