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Focusing our attention on LQT2, one of the most common subtypes of LQTS caused by mutations in the human ether\u2010\u00e0\u2010go\u2010go\u2010related gene (\n                    <jats:italic>hERG<\/jats:italic>\n                    ), in the present work, the stereoselectivity of the recently discovered mexiletine\u2010derived urea\n                    <jats:bold>8<\/jats:bold>\n                    was investigated on the hERG potassium channel. According to preliminary in silico predictions, in vitro studies revealed a stereoselective behavior, with the\n                    <jats:italic>meso<\/jats:italic>\n                    form showing the greatest hERG opening activity. In addition, functional studies on guinea pig isolated left atria, aorta, and ileum demonstrated that\n                    <jats:bold>8<\/jats:bold>\n                    does not present any cardiac or intestinal liability in our ex vivo studies. Due to its overall profile, (\n                    <jats:italic>R,S<\/jats:italic>\n                    )\u2010\n                    <jats:bold>8<\/jats:bold>\n                    paves the way for the design and development of a new series of compounds potentially useful in the treatment of both congenital and drug\u2010induced forms of LQTS.\n                  <\/jats:p>","DOI":"10.1002\/ardp.202300116","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T22:05:20Z","timestamp":1689631520000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["hERG stereoselective modulation by mexiletine\u2010derived ureas: Molecular docking study, synthesis, and biological evaluation"],"prefix":"10.1002","volume":"356","author":[{"given":"Gualtiero","family":"Milani","sequence":"first","affiliation":[{"name":"Department of Pharmacy\u2014Pharmaceutical Sciences University of Bari Aldo Moro Bari 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