{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:02:49Z","timestamp":1790694169740,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The development of novel antimycobacterial agents is an urgent challenge to eradicate the increasing emergence and rapid spread of multidrug\u2010resistant strains. Filamentous temperature\u2010sensitive protein Z (FtsZ) is a crucial cell division protein. Alteration of FtsZ assembly leads to cell division inhibition and cell death. To find novel antimycobacterial agents, a series of\n                    <jats:italic>N<\/jats:italic>\n                    <jats:sup>1<\/jats:sup>\n                    \u2010(benzo[\n                    <jats:italic>d<\/jats:italic>\n                    ]oxazol\u20102\u2010yl)\u2010\n                    <jats:italic>N<\/jats:italic>\n                    <jats:sup>4<\/jats:sup>\n                    \u2010arylidine compounds\n                    <jats:bold>5a\u2013o<\/jats:bold>\n                    were synthesized. The activity of the compounds was evaluated against drug\u2010sensitive, multidrug\u2010resistant, and extensive\u2010drug\u2010resistant\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    . Compounds\n                    <jats:bold>5b<\/jats:bold>\n                    ,\n                    <jats:bold>5c<\/jats:bold>\n                    ,\n                    <jats:bold>5l<\/jats:bold>\n                    ,\n                    <jats:bold>5m<\/jats:bold>\n                    , and\n                    <jats:bold>5o<\/jats:bold>\n                    showed promising antimycobacterial activity with minimum inhibitory concentrations (MIC) in the range of 0.48\u20131.85\u2009\u00b5g\/mL and with low cytotoxicity against human nontumorigenic lung fibroblast WI\u201038 cells. The activity of the compounds\n                    <jats:bold>5b<\/jats:bold>\n                    ,\n                    <jats:bold>5c<\/jats:bold>\n                    ,\n                    <jats:bold>5l<\/jats:bold>\n                    ,\n                    <jats:bold>5m<\/jats:bold>\n                    , and\n                    <jats:bold>5o<\/jats:bold>\n                    was evaluated against bronchitis causing\u2010bacteria. They exhibited good activity against\n                    <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n                    ,\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    ,\n                    <jats:italic>Mycoplasma pneumonia<\/jats:italic>\n                    , and\n                    <jats:italic>Bordetella pertussis<\/jats:italic>\n                    . Molecular dynamics simulations of Mtb FtsZ protein\u2010ligand complexes identified the interdomain site as the binding site and key interactions. ADME prediction indicated that the synthesized compounds have drug\u2010likeness. The density function theory studies of\n                    <jats:bold>5c<\/jats:bold>\n                    ,\n                    <jats:bold>5l<\/jats:bold>\n                    , and\n                    <jats:bold>5n<\/jats:bold>\n                    were performed to investigate\n                    <jats:italic>E\/Z<\/jats:italic>\n                    isomerization. Compounds\n                    <jats:bold>5c<\/jats:bold>\n                    and\n                    <jats:bold>5l<\/jats:bold>\n                    are present as\n                    <jats:italic>E<\/jats:italic>\n                    \u2010isomers and\n                    <jats:bold>5n<\/jats:bold>\n                    as an\n                    <jats:italic>E\/Z<\/jats:italic>\n                    mixture. Our experimental outcomes provide an auspicious lead for the design of more selective and potent antimycobacterial drugs.\n                  <\/jats:p>","DOI":"10.1002\/ardp.202300187","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T22:39:15Z","timestamp":1686177555000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Targeting\n                    <i>Mycobacterium tuberculosis<\/i>\n                    : Synthesis, in vitro and in silico evaluation of novel\n                    <i>N<\/i>\n                    <sup>1<\/sup>\n                    \u2010(benzo[\n                    <i>d<\/i>\n                    ]oxazol\u20102\u2010yl)\u2010\n                    <i>N<\/i>\n                    <sup>4<\/sup>\n                    \u2010arylidine compounds"],"prefix":"10.1002","volume":"356","author":[{"given":"Amira 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Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Taha","sequence":"additional","affiliation":[{"name":"Materials Science and Nanotechnology Department, Faculty of Postgraduate Studies for Advanced Sciences Beni\u2010Suef University Beni\u2010Suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9487-1100","authenticated-orcid":false,"given":"Claire","family":"Simons","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences Cardiff University Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8658-1296","authenticated-orcid":false,"given":"Samar S.","family":"Elbaramawi","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Faculty of Pharmacy Zagazig University Zagazig 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