{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:58:46Z","timestamp":1790053126430,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014824","name":"Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014824","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pericles.pericles-gcp.literatumonline.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rhodanine and its derivatives are an important class of heterocycles with diverse biological properties, including anticancer, antibacterial, and anti\u2010mycobacterial activities. In the present work, four series of new Rhodanine derivatives were synthesized and evaluated for their inhibitory activity against carbonic anhydrase I, II, IX, and XII isoforms. Interestingly, the tested compounds exhibited good inhibitory activity against the cytosolic isoform human carbonic anhydrase (hCA) II and tumor\u2010associated hCA IX. While the Rhodanine\u2010benzylidene derivatives (<jats:bold>3a\u2013l<\/jats:bold>) and Rhodanine\u2010hydrazine derivatives (<jats:bold>6a\u2013e<\/jats:bold>) are found to be selective against hCA II, the Rhodanine\u2010<jats:italic>N<\/jats:italic>\u2010carboxylate derivatives (<jats:bold>8a\u2013d<\/jats:bold>) are found to be highly selective toward hCA IX. The Rhodanine\u2010linked isoxazole and 1,2,4\u2010oxadiazole derivatives (<jats:bold>8ba<\/jats:bold>, <jats:bold>8da<\/jats:bold>, and <jats:bold>8db<\/jats:bold>) exhibited inhibitory activity against hCA II and hCA IX. Among the tested compounds, <jats:bold>3b<\/jats:bold>, <jats:bold>3j<\/jats:bold>, <jats:bold>6d<\/jats:bold>, and <jats:bold>8db<\/jats:bold> were found to inhibit hCA II with <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> values of 9.8, 46.4, 7.7, and 4.7\u2009\u00b5M, respectively. Furthermore, their mechanism of action is supported by molecular docking studies. Notably, the synthesized Rhodanine derivatives belong to a nonsulfonamide class of carbonic anhydrase inhibitors.<\/jats:p>","DOI":"10.1002\/ardp.202300205","type":"journal-article","created":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T02:59:31Z","timestamp":1688180371000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Design, synthesis, and structure\u2013activity studies of new rhodanine derivatives as carbonic anhydrase II, IX inhibitors"],"prefix":"10.1002","author":[{"given":"Krishna Kartheek","family":"Chinchilli","sequence":"first","affiliation":[{"name":"Department of Chemical Sciences National Institute of Pharmaceutical Education and Research (NIPER)  Balanagar Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravikumar","family":"Akunuri","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences National Institute of Pharmaceutical Education and Research (NIPER)  Balanagar Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaik Mahammad","family":"Ghouse","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences National Institute of Pharmaceutical Education and Research (NIPER)  Balanagar Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devandla","family":"Soujanya","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences National Institute of Pharmaceutical Education and Research (NIPER)  Balanagar Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Angeli","sequence":"additional","affiliation":[{"name":"Neurofarba Dept. Sezione di Scienze Farmaceutiche e Nutraceutiche, Sesto Fiorentino Universit\u00e0 degli Studi di Firenze  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramulu","family":"Parupalli","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences National Institute of Pharmaceutical Education and Research (NIPER)  Balanagar Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0158-5683","authenticated-orcid":false,"given":"Mohammed","family":"Arifuddin","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Directorate of Distance Education Maulana Azad National Urdu University  Gachibowli Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9813-8694","authenticated-orcid":false,"given":"Venkata Madhavi","family":"Yaddanapudi","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences National Institute of Pharmaceutical Education and Research (NIPER)  Balanagar Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"Neurofarba Dept. Sezione di Scienze Farmaceutiche e Nutraceutiche, Sesto Fiorentino Universit\u00e0 degli Studi di Firenze  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivas","family":"Nanduri","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences National Institute of Pharmaceutical Education and Research (NIPER)  Balanagar Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20160115"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2019.1626376"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2021.127856"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00018.2021"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161208783877884"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2467"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2012.04.044"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/ie060287u"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2020.115496"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.10.5.575"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom3030553"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2016.1203904"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.10025"},{"key":"e_1_2_7_15_1","first-page":"709","volume":"32","author":"Rahman S.","year":"2019","journal-title":"Pak. 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