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These properties apparently influence the interactions of benzoxazolone\u2010based derivatives with their respective biological targets. Hence, the benzoxazolone ring is implicated in the synthesis and development of pharmaceuticals with a diverse biological profile ranging from anticancer, analgesics, insecticides, anti\u2010inflammatory, and neuroprotective agents. This has further led to the commercialization of several benzoxazolone\u2010based molecules and a few others under clinical trials. Nevertheless, the SAR exploration of benzoxazolone derivatives for the identification of potential \u201chits\u201d followed by the screening of \u201cleads\u201d provides a plethora of opportunities for further exploration of the pharmacological profile of the benzoxazolone nucleus. In this review, we aim to present the biological profile of different derivatives based on the benzoxazolone framework.<\/jats:p>","DOI":"10.1002\/ardp.202300245","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T12:46:01Z","timestamp":1687956361000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Synthesis and biological profile of benzoxazolone derivatives"],"prefix":"10.1002","volume":"356","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9412-9424","authenticated-orcid":false,"given":"Parteek","family":"Prasher","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Petroleum &amp; Energy Studies, Energy Acres Dehradun India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanisqa","family":"Mall","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Petroleum &amp; Energy Studies, Energy Acres Dehradun India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mousmee","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Chemistry Uttaranchal University Dehradun India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,28]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867053507388"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M305490200"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/156802606776894456"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.22033"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1254\/fpj.77.245"},{"key":"e_1_2_16_7_1","first-page":"785","volume":"18","author":"Mazaheri F.","year":"2020","journal-title":"Int. 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