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The results indicate that the triazole\u2010ring\u2010containing compounds have strong inhibitory effects on hCA I, hCA II,\u00a0acetylcholinesterase (AChE),\u00a0and butyrylcholinesterase (BuChE) targets. Besides comparing the Schiff bases synthesized in our study to reference molecules, we conducted in silico investigations to examine how these compounds interact with their targets. Our studies revealed that these compounds can occupy binding sites and establish interactions with crucial residues, thus inhibiting the functions of the targets. These findings have significant implications as they can be utilized to develop more potent compounds for treating the diseases that these target proteins play crucial roles in or to obtain drug precursors with enhanced efficacy.<\/jats:p>","DOI":"10.1002\/ardp.202300266","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T19:01:51Z","timestamp":1712689311000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Efficient, rapid, and high\u2010yield synthesis of aryl Schiff base derivatives and their in vitro and in silico inhibition studies of hCA I, hCA II, AChE, and BuChE"],"prefix":"10.1002","volume":"357","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1980-1364","authenticated-orcid":false,"given":"Musa","family":"\u00d6zil","sequence":"first","affiliation":[{"name":"Department of Chemistry The Faculty of Arts and Sciences Recep Tayyip Erdogan University Rize T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2823-4004","authenticated-orcid":false,"given":"Halis T.","family":"Balayd\u0131n","sequence":"additional","affiliation":[{"name":"Education Faculty Recep Tayyip Erdogan University Rize T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9638-2896","authenticated-orcid":false,"given":"Berna","family":"Dogan","sequence":"additional","affiliation":[{"name":"Department of Chemistry Istanbul Technical University Istanbul T\u00fcrkiye"},{"name":"Department of Biochemistry School of Medicine Bah\u00e7e\u015fehir University Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5650-5177","authenticated-orcid":false,"given":"Murat","family":"\u015eent\u00fcrk","sequence":"additional","affiliation":[{"name":"Pharmacy Faculty Agri Ibrahim Cecen University Agri T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0426-0905","authenticated-orcid":false,"given":"Serdar","family":"Durdagi","sequence":"additional","affiliation":[{"name":"Computational Biology and Molecular Simulations Laboratory,\u00a0Department of Biophysics \u00a0School of Medicine Bah\u00e7e\u015fehir University Istanbul T\u00fcrkiye"},{"name":"Molecular Therapy Lab,\u00a0Department of Pharmaceutical Chemistry School of Pharmacy Bah\u00e7e\u015fehir University Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2467"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2022.2036137"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4324\/9780203475300"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7RA13674A"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2011.596836"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2011.12.069"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.01.077"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.10.021"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2018.04.008"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202100430"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.5b00313"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2016.01.080"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.01.014"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2004.09.072"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.04.079"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2004.02.014"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.05.017"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hc.20381"},{"key":"e_1_2_8_20_1","volume-title":"1. 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