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The triazole nucleus has been the cornerstone for the development of many enzyme inhibitors for the clinical management of several diseases, where hyperuricemia is one of them. Here, we give a critical overview of significant research on triazole\u2010based XO inhibitors, with respect to their design, synthesis, inhibition potential, toxicity, and docking studies, done till now. Based on these literature findings, we can expect a burst of modifications on triazole\u2010based scaffolds in the near future by targeting XO, which will treat hyperuricemics, that is, painful conditions like gout that at present are hard to deal with.<\/jats:p>","DOI":"10.1002\/ardp.202300296","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T04:56:53Z","timestamp":1704862613000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Triazole derivatives as potential xanthine oxidase inhibitors: Design, enzyme inhibition potential, and docking studies"],"prefix":"10.1002","volume":"357","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1968-8725","authenticated-orcid":false,"given":"Harmandeep Kaur","family":"Gulati","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences Guru Nanak Dev University Amritsar Punjab India"},{"name":"Dasmesh College of Pharmacy 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