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The synthesized compounds were investigated for inhibiting two human carbonic anhydrases, human carbonic anhydrases (hCA) I and II, and those of the bacterial pathogen <jats:italic>Mycobacterium tuberculosis<\/jats:italic>, mtCA 1\u20133. The results indicate that, among the synthesized compounds, pyrazoles with 4\u2010aminobenzene sulfonamide were more selective toward hCA I and II over mtCAs, and compounds with 3\u2010aminobenzene sulfonamide were selective toward mtCA 1\u20133 over hCA I, II. Compound <jats:bold>6g<\/jats:bold> showed significant and selective inhibition toward hCA I and II, with <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> values of 0.0366 and 0.0310\u2009\u00b5M, respectively. Compound <jats:bold>5g<\/jats:bold> exhibited the best inhibition toward mtCA 2, with a <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> value of 0.0617\u2009\u00b5M. Among the benzamides, compound <jats:bold>9b<\/jats:bold> exhibited significant activity toward mtCA 2, with a <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> value of 0.0696\u2009\u00b5M. Selectivity of these compounds was further supported by docking studies. When tested for antitubercular activity, many compounds showed moderate to good inhibition against the Mtb H37Rv strain, with minimum inhibitory concentration (MIC) values in the range of 4\u2013128\u2009\u00b5g\/mL.<\/jats:p>","DOI":"10.1002\/ardp.202300309","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T02:55:52Z","timestamp":1694400952000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Exploration of 3\u2010aryl pyrazole\u2010tethered sulfamoyl carboxamides as carbonic anhydrase inhibitors"],"prefix":"10.1002","volume":"356","author":[{"given":"Ojaswitha","family":"Ommi","sequence":"first","affiliation":[{"name":"Department of Chemical Sciences National Institute of Pharmaceutical Education and Research (NIPER), Balanagar  Hyderabad Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niccol\u00f2","family":"Paoletti","sequence":"additional","affiliation":[{"name":"Department NEUROFARBA, Pharmaceutical and Nutraceutical Section University of Florence  Sesto Fiorentino (Florence) Italy"},{"name":"Laboratory of Molecular Modeling Cheminformatics &amp; 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