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The majority of the compounds were found to be effective inhibitors of tumor\u2010associated hCA IX and XII, and poor inhibitors of cytosolic hCA I. Despite the strong to moderate inhibition potential possessed by these compounds toward another cytosolic isoform hCA II, some of them demonstrated better potency against hCA IX and\/or XII isoforms as compared to hCA II. Four compounds (<jats:bold>11f<\/jats:bold>, <jats:bold>11g<\/jats:bold>, <jats:bold>12c<\/jats:bold>, and <jats:bold>12g<\/jats:bold>) effectively inhibited hCA IX and\/or XII isoforms with considerable selectivity over the off\u2010targets hCA I and II. Interestingly, five compounds,\u00a0including <jats:bold>11f<\/jats:bold>, <jats:bold>11g<\/jats:bold>, <jats:bold>12c<\/jats:bold>, <jats:bold>12d<\/jats:bold>, and <jats:bold>12g<\/jats:bold>, inhibited hCA IX even better than the clinically used acetazolamide. Some of the novel synthesized compounds exhibited higher anti\u2010cathepsin B potential than acetazolamide, with % inhibition of around 50%, at a concentration of 10<jats:sup>\u22127<\/jats:sup>\u2009M. Further, two compounds (<jats:bold>12g<\/jats:bold> and <jats:bold>12c<\/jats:bold>) that showed effective and selective inhibition activity profiles against hCA IX and XII were additionally found to be effective inhibitors of cathepsin B.<\/jats:p>","DOI":"10.1002\/ardp.202300349","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T03:11:05Z","timestamp":1694661065000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Potent inhibitors of tumor associated carbonic anhydrases endowed with cathepsin B inhibition"],"prefix":"10.1002","volume":"356","author":[{"given":"Amit","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Chemistry Kurukshetra University  Kurukshetra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Arya","sequence":"additional","affiliation":[{"name":"Department of Chemistry Kurukshetra University  Kurukshetra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Chemistry Kurukshetra University  Kurukshetra India"},{"name":"Department of Chemistry Pt. 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