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The compounds were evaluated for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity, revealing several derivatives to possess AChE inhibition comparable to that of the AChE inhibitor rivastigmine. The binding mode of the AChE inhibitor donepezil and selected active compounds <jats:bold>26<\/jats:bold> and <jats:bold>27<\/jats:bold> within the active site of AChE was studied using molecular docking. Furthermore, the neuroprotective activity of the prepared compounds was evaluated in models associated with Parkinson's disease (salsolinol\u2010induced) and aspects of Alzheimer's disease (glutamate\u2010induced oxidative damage). Compound <jats:bold>28<\/jats:bold> showed the highest neuroprotective effect in both salsolinol\u2010 and glutamate\u2010induced neurodegeneration models, and its protective effect in the glutamate model was revealed to be driven by a reduction in oxidative stress and caspase\u20103\/7 activity.<\/jats:p>","DOI":"10.1002\/ardp.202300378","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T17:26:50Z","timestamp":1696613210000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Synthesis and neuroprotective activity of 3\u2010aryl\u20103\u2010azetidinyl acetic acid methyl ester derivatives"],"prefix":"10.1002","volume":"356","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0268-5981","authenticated-orcid":false,"given":"Urt\u0117","family":"\u0160achlevi\u010di\u016bt\u0117","sequence":"first","affiliation":[{"name":"Institute of Synthetic Chemistry Kaunas University of Technology Kaunas Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8196-878X","authenticated-orcid":false,"given":"Gabriel","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Experimental Biology, Faculty of Science Palack\u00fd University Olomouc  Olomouc Czech Republic"},{"name":"Department of Neurology, University Hospital Olomouc and Faculty of Medicine and Dentistry Palack\u00fd University Olomouc Olomouc Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3603-0749","authenticated-orcid":false,"given":"Marie","family":"Kvasnicov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Experimental Biology, Faculty of Science Palack\u00fd University Olomouc  Olomouc Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1969-5258","authenticated-orcid":false,"given":"\u0160\u00e1rka","family":"\u0160t\u011bp\u00e1nkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Biological and Biochemical Sciences, Faculty of Chemical Technology University of Pardubice Pardubice Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1390-1265","authenticated-orcid":false,"given":"Neringa","family":"Kleizien\u0117","sequence":"additional","affiliation":[{"name":"Institute of Synthetic Chemistry Kaunas University of Technology Kaunas Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3838-261X","authenticated-orcid":false,"given":"Aurimas","family":"Bieliauskas","sequence":"additional","affiliation":[{"name":"Institute of Synthetic Chemistry Kaunas University of Technology Kaunas Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9962-2798","authenticated-orcid":false,"given":"Marek","family":"Zatloukal","sequence":"additional","affiliation":[{"name":"Department of Chemical Biology, Faculty of Science Palack\u00fd University Olomouc Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2806-794X","authenticated-orcid":false,"given":"Miroslav","family":"Strnad","sequence":"additional","affiliation":[{"name":"Laboratory of Growth Regulators Institute of Experimental Botany of the Czech Academy of Sciences &amp; 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