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Unfortunately, its use is associated with toxicities of several organs.<jats:italic>Stenocarpus sinuatus<\/jats:italic>is an Australian tree belonging to the Proteaceae family. In the current study, the phytochemical constituents of<jats:italic>S. sinuatus<\/jats:italic>methanol leaf extract (SSLE) were assessed. In addition, the protective effect of SSLE against IFOS\u2010induced nephrotoxicity and hepatotoxicity was evaluated. Rats were randomly divided into six groups: control, IFOS (50\u2009mg\/kg), IFOS\u2009+\u2009SSLE (100\u2009mg\/kg), IFOS\u2009+\u2009SSLE (200\u2009mg\/kg), IFOS\u2009+\u2009SSLE (400\u2009mg\/kg), and SSLE (400\u2009mg\/kg). Hepatoprotective and nephroprotective potency of SSLE was assessed using different biochemical parameters. The phytochemical investigation resulted in the isolation of four flavonoid glycosides (kaempferol 3\u2010<jats:italic>O<\/jats:italic>\u2010<jats:italic>\u03b2<\/jats:italic>\u2010<jats:sc>d<\/jats:sc>\u2010glucopyranosyl\u2010(1\u21922)\u2010<jats:italic>\u03b1<\/jats:italic>\u2010<jats:sc>l<\/jats:sc>\u2010rhamnopyranoside, kaempferol 3\u2010<jats:italic>O<\/jats:italic>\u2010<jats:italic>\u03b1<\/jats:italic>\u2010rhamnopyranoside, isorhamnetin 3\u2010<jats:italic>O<\/jats:italic>\u2010<jats:italic>\u03b2<\/jats:italic>\u2010<jats:sc>d<\/jats:sc>\u2010glucopyranosyl\u2010(1\u21922)\u2010<jats:italic>\u03b1<\/jats:italic>\u2010<jats:sc>l<\/jats:sc>\u2010rhamnopyranoside, and quercetin 3\u2010<jats:italic>O<\/jats:italic>\u2010<jats:italic>\u03b2<\/jats:italic>\u2010<jats:sc>d<\/jats:sc>\u2010glucopyranosyl\u2010(1\u21922)\u2010<jats:italic>\u03b1<\/jats:italic>\u2010<jats:sc>l<\/jats:sc>\u2010rhamnopyranoside) and a coumarin (scopoletin). This is the first report on the isolated compounds from the genus<jats:italic>Stenocarpus<\/jats:italic>. SSLE showed enhancement of kidney and liver functions and reduction of oxidative stress and inflammation. The histopathology of the investigated organs confirmed the protective effect of SSLE. In conclusion, SSLE is considered as a promising candidate that can be used in defense against the toxic effects of IFOS after further clinical trials.<\/jats:p>","DOI":"10.1002\/ardp.202300438","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T22:18:22Z","timestamp":1700605102000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["In vivo hepatoprotective and nephroprotective effects of<i>Stenocarpus sinuatus<\/i>leaf extract against ifosfamide\u2010induced toxicity in rats"],"prefix":"10.1002","volume":"357","author":[{"given":"Mai M.","family":"Younis","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Ain Shams University, Abbassia Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iriny M.","family":"Ayoub","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Ain Shams University, Abbassia Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina Y.","family":"George","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy Ain Shams University, Abbassia Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada M.","family":"Mostafa","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Ain Shams University, Abbassia Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0972-0560","authenticated-orcid":false,"given":"Omayma A.","family":"Eldahshan","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Ain Shams University, Abbassia Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-79139-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/138955706776361385"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfz183"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740330902808169"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2006.05.006"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2005.01582.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26717"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2008.04.008"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.931128"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2016.1246575"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201800045"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-020-00749-9"},{"issue":"11","key":"e_1_2_7_14_1","first-page":"860","volume":"69","author":"Nawwar M. 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