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We have synthesized a series of novel 2\u2010(pyridylvinyl)chromen\u20104\u2010ones and their pyridine <jats:italic>N<\/jats:italic>\u2010oxides to evaluate them as potential anticancer agents against human non\u2010small\u2010cell lung cancer cells (A549). Among the 18 synthesized molecules, compounds <jats:bold>18<\/jats:bold> and <jats:bold>8a<\/jats:bold> exhibited comparable inhibitory effects to 5\u2010fluorouracil and showed no toxicity against normal cells.<\/jats:p>","DOI":"10.1002\/ardp.202300445","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T17:05:20Z","timestamp":1705424720000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis of 2\u2010(pyridylvinyl)chromen\u20104\u2010ones and their <i>N<\/i>\u2010oxide analogs for assessment of their biological activities as anticancer agents"],"prefix":"10.1002","volume":"357","author":[{"given":"Yu Chun","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Chemistry Tamkang University New Taipei City 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