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This study was conducted to determine the bio\u2010pharmaceutical potential and phenolic contents of six different extracts from aerial parts of <jats:italic>Stachys tundjeliensis<\/jats:italic>. The obtained results showed that the ethanol extract exhibited the highest antioxidant activity in the antioxidant assays. Meanwhile, the ethanol extract displayed strong inhibitory activity against \u03b1\u2010tyrosinase, the dichloromethane extract exhibited potent inhibition against butyrylcholinesterase, and the <jats:italic>n<\/jats:italic>\u2010hexane extract against \u03b1\u2010amylase. Based on ultra\u2010high performance liquid chromatography coupled to high\u2010resolution mass spectrometry\u00a0analysis, more than 90 secondary metabolites, including hydroxybenzoic acid, hydroxycinnamic acid, and their glycosides, acylquinic acids, phenylethanoid glycosides, and various flavonoids were identified or tentatively annotated in the studied <jats:italic>S. tundjeliensis<\/jats:italic> extracts. It was observed that the application of <jats:italic>S. tundjeliensis<\/jats:italic> eliminated H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>\u2010induced oxidative stress. It was determined that protein levels of phospho\u2010nuclear factor kappa B (NF\u2010\u03baB), receptor for advanced glycation endproducts, and activator protein\u20101, which are activated in the nucleus, decreased, and the synthesis of matrix metalloproteinase (MMP)\u20102 and MMP\u20109 also decreased to basal levels. Overall, these findings suggest that S. <jats:italic>tundjeliensis<\/jats:italic> contains diverse bioactive compounds for the development of nutraceuticals or functional foods with potent biological properties.<\/jats:p>","DOI":"10.1002\/ardp.202300528","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T08:43:32Z","timestamp":1700210612000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Uncovering chemical profiles, biological potentials, and protection effect against ECM destruction in H<sub>2<\/sub>O<sub>2<\/sub>\u2010treated HDF cells of the extracts of <i>Stachys tundjeliensis<\/i>"],"prefix":"10.1002","volume":"357","author":[{"given":"Inci","family":"Kurt\u2010Celep","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Acibadem Mehmet Ali Aydinlar University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrina","family":"Zheleva\u2010Dimitrova","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Medical University of Sofia  Sofia Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouadio Ibrahime","family":"Sinan","sequence":"additional","affiliation":[{"name":"Department of Biology, Science Faculty Selcuk University  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullahi Ibrahim","family":"Uba","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics Istanbul AREL University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Nilofar","sequence":"additional","affiliation":[{"name":"Department of Biology, Science Faculty Selcuk University  Konya Turkey"},{"name":"Department of Pharmacy, Botanic Garden \u201cGiardino dei Semplici\u201d Universit\u00e0 degli Studi \u201cGabriele d'Annunzio\u201d  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad Fawzi","family":"Mahomoodally","sequence":"additional","affiliation":[{"name":"Institute of Research and Development Duy Tan University  Da Nang Vietnam"},{"name":"School of Engineering &amp; Technology Duy Tan University  Da Nang Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Zakariyyah","family":"Aumeeruddy","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Faculty of Medicine and Health Sciences University of Mauritius  R\u00e9duit Mauritius"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3627-3604","authenticated-orcid":false,"given":"Ugur","family":"Cakilcioglu","sequence":"additional","affiliation":[{"name":"Pertek Sakine Gen\u00e7 Vocational School Munzur University  Pertek Tunceli Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Dall'Acqua","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Pharmacological Sciences University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6548-7823","authenticated-orcid":false,"given":"Gokhan","family":"Zengin","sequence":"additional","affiliation":[{"name":"Department of Biology, Science Faculty Selcuk University  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2017.1356838"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants10061054"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.11646\/phytotaxa.516.3.4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.55730\/1300-008X.2737"},{"issue":"1","key":"e_1_2_7_6_1","first-page":"81","volume":"9","author":"Tundis R.","year":"2015","journal-title":"Rec. 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