{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T21:07:39Z","timestamp":1785013659601,"version":"3.55.0"},"reference-count":65,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The genus <jats:italic>Albizia<\/jats:italic> is one of the richest genera in phenolics besides other classes of secondary metabolites including saponins, terpenes, and alkaloids with promising medicinal applications. In the current study, UHPLC\u2010PDA\u2010ESI\u2010MS\/MS\u2010based metabolic profiling of leaves of <jats:italic>Albizia lebbeck<\/jats:italic>, <jats:italic>Albizia julibrissin<\/jats:italic>, <jats:italic>Albizia odoratissima<\/jats:italic>, <jats:italic>Albizia procera<\/jats:italic>, <jats:italic>Albizia anthelmintica<\/jats:italic>, <jats:italic>Albizia guachapele<\/jats:italic>, <jats:italic>Albizia myriophylla<\/jats:italic>, <jats:italic>Albizia richardiana<\/jats:italic>, and <jats:italic>Albizia lucidior<\/jats:italic> resulted in the tentative identification of 64 metabolites, mainly flavonoids, phenolic acids, saponins, and alkaloids. Some metabolites were identified in <jats:italic>Albizia<\/jats:italic> for the first time and could be used as species\u2010specific chemotaxonomic markers, including: apigenin 7\u2010<jats:italic>O<\/jats:italic>\u2010dihydroferuloyl hexoside isomers, apigenin 7\u2010<jats:italic>O<\/jats:italic>\u2010pentosyl hexoside, quercetin 3\u2010<jats:italic>O<\/jats:italic>\u2010rutinoside 7\u2010<jats:italic>O<\/jats:italic>\u2010deoxyhexoside, quercetin 3,7\u2010di\u2010<jats:italic>O<\/jats:italic>\u2010hexoside deoxyhexoside, quercetin 7\u2010<jats:italic>O<\/jats:italic>\u2010feruloyl hexoside, methyl myricetin 7\u2010<jats:italic>O<\/jats:italic>\u2010deoxyhexoside, kaempferol di\u20103\u2010<jats:italic>O<\/jats:italic>\u2010di\u2010deoxyhexoside\u20107\u2010<jats:italic>O<\/jats:italic>\u2010hexoside, and kaempferol 3\u2010<jats:italic>O<\/jats:italic>\u2010neohesperidoside 7\u2010<jats:italic>O<\/jats:italic>\u2010hexoside. Comparative untargeted metabolomic analysis was undertaken to discriminate between species and provide a chemotaxonomic clue that can be used together with morphological and genetic analyses for more accurate classification within this genus. Moreover, the in vitro antiplasmodial activity was assessed and correlated to the metabolic profile of selected species. This was followed by a molecular docking study and absorption, distribution, metabolism, excretion, and toxicity (ADMET) prediction of the identified budmunchiamine alkaloids, revealing promising interactions with the active site of lactate dehydrogenase of <jats:italic>Plasmodium falciparum<\/jats:italic> and good pharmacokinetics and pharmacodynamics, which could help in designing novel antimalarial drugs.<\/jats:p>","DOI":"10.1002\/ardp.202300543","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T22:36:21Z","timestamp":1709073381000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A comparative untargeted metabolomic analysis and assessment of antiplasmodial potential of nine <i>Albizia<\/i> species"],"prefix":"10.1002","volume":"357","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5789-8283","authenticated-orcid":false,"given":"Yosra A.","family":"El Khodary","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Ain Shams University Abbassia Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2382-8241","authenticated-orcid":false,"given":"Iriny M.","family":"Ayoub","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Ain Shams University Abbassia Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4413-2948","authenticated-orcid":false,"given":"Pierre","family":"P\u00e9rio","sequence":"additional","affiliation":[{"name":"Faculte des Sciences Pharmaceutiques, Pharma\u2010Dev, UMR 152 Universit\u00e9 de Toulouse III\u2010Paul Sabatier, IRD, UPS Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Bourgeade\u2010Delmas","sequence":"additional","affiliation":[{"name":"Faculte des Sciences Pharmaceutiques, Pharma\u2010Dev, UMR 152 Universit\u00e9 de Toulouse III\u2010Paul Sabatier, IRD, UPS Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nehal","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Ain Shams University Abbassia Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherweit H.","family":"El\u2010Ahmady","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Ain Shams University Abbassia Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"issue":"3","key":"e_1_2_8_2_1","first-page":"70","volume":"5","author":"Kokila K.","year":"2013","journal-title":"Int. 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