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Commercially available 3,4\u2010dimethoxytoluene was reacted with chlorosulfonic acid to furnish benzene sulfonyl chloride derivatives. The reaction of substituted benzene sulfonyl chloride with some amines also including (\u00b1)\u2010\u03b1\u2010amino acid methyl esters afforded a series of novel benzene sulfonamides. In this study, the enzyme inhibition abilities of these compounds were evaluated against AChE and CAs. They exhibited a highly potent inhibition ability on AChE and \u2010CAs (<jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> values are in the range of 28.11\u2009\u00b1\u20094.55\u2009nM and 145.52\u2009\u00b1\u200928.68\u2009nM for AChE, 39.20\u2009\u00b1\u20092.10\u2009nM to 131.54\u2009\u00b1\u200912.82\u2009nM for CA I, and 50.96\u2009\u00b1\u20099.83\u2009nM and 147.94\u2009\u00b1\u200918.75\u2009nM for CA II). The present newly synthesized novel benzene sulfonamides displayed efficient inhibitory profiles against AChE and CAs, and it is anticipated that they may emerge as lead molecules for some diseases including glaucoma, epilepsy, and Alzheimer's disease.<\/jats:p>","DOI":"10.1002\/ardp.202300545","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T03:00:56Z","timestamp":1709262056000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Novel benzene sulfonamides with acetylcholinesterase and carbonic anhydrase inhibitory actions"],"prefix":"10.1002","volume":"357","author":[{"given":"Rafika","family":"El Ati","sequence":"first","affiliation":[{"name":"Laboratory of Applied Chemistry and Environment (LCAE), Faculty of Sciences University Mohammed the first Oujda Morocco"},{"name":"Department of Chemistry, Faculty of Science Atat\u00fcrk University Erzurum Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Necla","family":"\u00d6zta\u015fk\u0131n","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Atat\u00fcrk University Erzurum Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"\u00c7a\u011fan","sequence":"additional","affiliation":[{"name":"Central Researching Laboratory Agri Ibrahim Cecen University  Agri Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6473-6338","authenticated-orcid":false,"given":"Ak\u0131n","family":"Ak\u0131nc\u0131o\u011flu","sequence":"additional","affiliation":[{"name":"Central Researching Laboratory Agri Ibrahim Cecen University  Agri Turkiye"},{"name":"Vocational School A\u011fr\u0131 \u0130brahim \u00c7e\u00e7en University  Agri Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3216-1098","authenticated-orcid":false,"given":"Yeliz","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services Ardahan University Ardahan Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1280-3954","authenticated-orcid":false,"given":"S\u00fcleyman","family":"G\u00f6ksu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Atat\u00fcrk University Erzurum Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachid","family":"Touzani","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Chemistry and Environment (LCAE), Faculty of Sciences University Mohammed the first Oujda Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lhami","family":"G\u00fcl\u00e7in","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Atat\u00fcrk University Erzurum Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24119687"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2019.1664501"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2022.2138367"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc-2021-0222"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20210040"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32205-4"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232213954"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205018666211215150547"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.11.017"},{"key":"e_1_2_8_11_1","first-page":"194","volume":"8","author":"Das T. 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