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To prepare liposomes, a series of novel multivalent glutamic hexapeptide derivatives were designed and synthesized as liposome ligands, which can effectively deliver paclitaxel (PTX) to bone. The liposomes were prepared and their encapsulation efficiency, particle size, stability, zeta potential, hemolysis, and release behavior were characterized. The results indicated that the coated liposomes, PTX\u2010Glu6<jats:sub>1<\/jats:sub>\u2010Lip, PTX\u2010Glu6<jats:sub>2<\/jats:sub>\u2010Lip, PTX\u2010Glu6<jats:sub>3<\/jats:sub>\u2010Lip, and PTX\u2010Glu6<jats:sub>5<\/jats:sub>\u2010Lip, showed remarkable bone\u2010targeting activity. Compared with the other coated liposomes, PTX\u2010Glu6<jats:sub>5<\/jats:sub>\u2010Lip showed prominent targeting ability and anti\u2010bone metastasis activity on the basis of in vitro and in vivo evaluations. Our study may contribute to the field of design of bone\u2010targeting drugs.<\/jats:p>","DOI":"10.1002\/ardp.202300620","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T14:44:23Z","timestamp":1703256263000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Liposomes modified with a multivalent glutamic hexapeptide: A novel and effective way to promote bone targeting"],"prefix":"10.1002","volume":"357","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7344-9026","authenticated-orcid":false,"given":"Yi","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Translational Medicine Center the First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine Center the First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamin","family":"Cui","sequence":"additional","affiliation":[{"name":"Zhengzhou Immuno Bio\u2010Tech Co., Ltd  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics the First Affiliated Hospital of Henan Polytechnic University (the Second People's Hospital of Jiaozuo City)  Jiaozuo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine Center the First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2022.100881"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2023.101838"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.22514\/ejgo.2023.104"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2020.104882"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2019.104785"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2022.2050845"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2020.10.001"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2004.02.020"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.32383\/appdr\/137902"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2019.104832"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2022.103482"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.909408"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.23773"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2019.09.022"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114281"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.09.009"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1RA08136E"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matchemphys.2020.123265"}],"container-title":["Archiv der Pharmazie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ardp.202300620","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T03:59:11Z","timestamp":1710820751000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ardp.202300620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,22]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/ardp.202300620"],"URL":"https:\/\/doi.org\/10.1002\/ardp.202300620","archive":["Portico"],"relation":{},"ISSN":["0365-6233","1521-4184"],"issn-type":[{"value":"0365-6233","type":"print"},{"value":"1521-4184","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,22]]},"assertion":[{"value":"2023-10-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2300620"}}