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When the results were examined, novel synthesized pyrimidine derivatives were found to have effective inhibition abilities toward the metabolic enzymes. IC<jats:sub>50<\/jats:sub> values and <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> values were calculated for each pyrimidine derivative and compared to positive controls. The synthesized novel pyrimidine derivatives exhibited <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> values in the range of 39.16\u2009\u00b1\u20097.70\u2013144.62\u2009\u00b1\u200926.98\u2009nM against hCA I, 18.21\u2009\u00b1\u20093.66\u2013136.35\u2009\u00b1\u200921.48\u2009nM toward\u00a0hCA II, which is associated with different pathological and physiological processes, 33.15\u2009\u00b1\u20094.85\u201352.98\u2009\u00b1\u200919.86\u2009nM on AChE, and 31.96\u2009\u00b1\u20098.24\u201369.57\u2009\u00b1\u200921.27\u2009nM on BChE. Also, <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> values were determined in the range of 17.37\u2009\u00b1\u20091.11\u2013253.88\u2009\u00b1\u200939.91\u2009nM against \u03b1\u2010glycosidase and 648.82\u2009\u00b1\u200953.74\u20131902.58\u2009\u00b1\u200998.90\u2009nM toward\u00a0AR enzymes. Within the scope of the study, the inhibition types of the novel synthesized pyrimidine derivatives were evaluated.<\/jats:p>","DOI":"10.1002\/ardp.202300634","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T19:59:47Z","timestamp":1716321587000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Synthesis and biological studies of pyrimidine derivatives targeting metabolic enzymes"],"prefix":"10.1002","volume":"357","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6375-8140","authenticated-orcid":false,"given":"Elif","family":"Korkusuz","sequence":"first","affiliation":[{"name":"Mustafa Cikrikcioglu Vocational College Kayseri University Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8836-8667","authenticated-orcid":false,"given":"Yusuf","family":"Sert","sequence":"additional","affiliation":[{"name":"Department of Physics, Faculty of Art &amp; 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