{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:01:57Z","timestamp":1753862517473,"version":"3.41.2"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A new series of isatin\u2010linked benzenesulfonamide derivatives (<jats:bold>9a\u2013w<\/jats:bold>) were synthesized using the tail approach and assayed for their inhibitory potency against four different human carbonic anhydrase (hCA) isoforms, hCA I, II, IX, and XII. Most of these synthesized compounds exhibited interesting inhibition potency against isoforms hCA I, IX, and XII in the nanomolar range and by taking the standard drug acetazolamide. The most potent compounds in the case of hCA I were <jats:bold>9c<\/jats:bold> (435.8\u2009nM) and <jats:bold>9s<\/jats:bold> (956.4\u2009nM), for hCA IX, <jats:bold>9a<\/jats:bold> (60.5\u2009nM), <jats:bold>9d<\/jats:bold> (95.6\u2009nM), <jats:bold>9g<\/jats:bold> (92.1\u2009nM), and <jats:bold>9k<\/jats:bold> (75.4\u2009nM), and for hCA XII, <jats:bold>9p<\/jats:bold> (84.5\u2009nM). However, these compounds showed more selectivity toward hCA IX over hCA I, II, and XII. Thus, these compounds can be further developed as potential lead molecules for the development of isoform\u2010selective hCA IX inhibitors with further structural modifications.<\/jats:p>","DOI":"10.1002\/ardp.202300718","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T14:09:43Z","timestamp":1710166183000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Design, synthesis, and biological evaluation of 3\u2010benzenesulfonamide\u2010linked 3\u2010hydrazinoisatin derivatives as carbonic anhydrase inhibitors"],"prefix":"10.1002","volume":"357","author":[{"given":"Baijayantimala","family":"Swain","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry National Institute of Pharmaceutical Education and Research (NIPER) Hyderabad Telangana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vaibhav S.","family":"Marde","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry National Institute of Pharmaceutical Education and Research (NIPER) Hyderabad Telangana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priti","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry National Institute of Pharmaceutical Education and Research (NIPER) Hyderabad Telangana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Angeli","sequence":"additional","affiliation":[{"name":"Neurofarba Department, Sezione di ScienzeFarmaceutiche e Nutraceutiche Universit\u00e0degliStudi di Firenze Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abrar","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry National Institute of Pharmaceutical Education and Research (NIPER) Hyderabad Telangana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkata M.","family":"Yaddanapudi","sequence":"additional","affiliation":[{"name":"Process Chemistry Process Technology, Department of Chemical Sciences National Institute of Pharmaceutical Education and Research (NIPER) Hyderabad Telangana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qasim","family":"Ullah","sequence":"additional","affiliation":[{"name":"Physical Sciences Section, School of Sciences Maulana Azad National Urdu University (MANUU) Hyderabad Telangana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"Neurofarba Department, Sezione di ScienzeFarmaceutiche e Nutraceutiche Universit\u00e0degliStudi di Firenze Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0158-5683","authenticated-orcid":false,"given":"Mohammed","family":"Arifuddin","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry National Institute of Pharmaceutical Education and Research (NIPER) Hyderabad Telangana India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2467"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2012.672983"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2013.787422"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2015.1122001"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2019.1651289"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23010153"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113486"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113490"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.112021"},{"key":"e_1_2_8_11_1","first-page":"4","volume":"6","author":"Grewal A. 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