{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:52:54Z","timestamp":1791942774535,"version":"4.3.4"},"reference-count":117,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the present study, we aimed to investigate the chemical profiles and biological activities of different extracts (ethyl acetate, dichloromethane, ethanol, and water) of <jats:italic>Pelargonium endlicherianum<\/jats:italic> parts (aerial parts and roots). Free radical scavenging, reducing power, phosphomolybdenum, and metal chelating were assayed for antioxidant properties. To detect enzyme inhibitory properties, cholinesterase, amylase, glucosidase, and tyrosinase were chosen as target enzymes. The ethanol extract of the aerial parts contained higher amounts of total bioactive compounds (120.53\u2009mg GAE\/g\u201024.46\u2009mg RE\/g). The ethanol and water extracts of these parts were tentatively characterized by UHPLC\u2010ESI\u2010QTOF\u2010MS and 95 compounds were annotated. In addition, the highest acetylcholiesterase (3.74\u2009mg GALAE\/g) and butyrylcholinesterase (3.92\u2009mg GALAE\/g) abilities were observed by the ethanol extract of roots. The water extract from aerial parts exhibited the most pronounced inhibitory effects on multiple cancer cell lines, especially A549 (IC<jats:sub>50<\/jats:sub>: 23.2\u2009\u00b5g\/mL) and HT\u201029 (IC<jats:sub>50<\/jats:sub>: 27.43\u2009\u00b5g\/mL) cells. Using network pharmacology, <jats:italic>P. endlicherianum<\/jats:italic> compounds were studied against cancer, revealing well\u2010connected targets such as epidermal growth factor receptor (EGFR), phosphoinositide\u20103\u2010kinase (PI3K), AKT, receptor tyrosine\u2010protein kinase erbB\u20102, and growth factor receptor bound protein 2 (GRB2) with significant impact on cancer\u2010related pathways. The results could open a new path from natural treasure to functional applications with <jats:italic>P. endlicherianum<\/jats:italic> and highlight a new study on other uninvestigated <jats:italic>Pelargonium<\/jats:italic> species.<\/jats:p>","DOI":"10.1002\/ardp.202300728","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T07:07:16Z","timestamp":1707289636000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["UHPLC\u2010ESI\u2010QTOF\u2010MS metabolite profiles of different extracts from <i>Pelargonium endlicherianum<\/i> parts and their biological properties based on network pharmacological approaches"],"prefix":"10.1002","volume":"357","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6548-7823","authenticated-orcid":false,"given":"Gokhan","family":"Zengin","sequence":"first","affiliation":[{"name":"Department of Biology, Science Faculty Selcuk University Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Javier","family":"Leyva\u2010Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry and Food Science and Technology University of Castilla\u2010La Mancha Ciudad Real Spain"},{"name":"Regional Institute for Applied Scientific Research (IRICA), Area of Food Science University of Castilla\u2010La Mancha Ciudad Real Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"Fern\u00e1ndez\u2010Ochoa","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Sciences University of Granada, Fuentenueva s\/n Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelhakim","family":"Bouyahya","sequence":"additional","affiliation":[{"name":"Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences Mohammed V University in Rabat Rabat Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evren","family":"Yildiztugay","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Science Faculty Selcuk University Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Segura","family":"Carretero","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Sciences University of Granada, Fuentenueva s\/n Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad Fawzi","family":"Mahomoodally","sequence":"additional","affiliation":[{"name":"Institute of Research and Development Duy Tan University Da Nang Vietnam"},{"name":"School of Engineering &amp; Technology Duy Tan University Da Nang Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sathish Kumar M","family":"Ponniya","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics Pondicherry University Pudhucherry India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Nilofar","sequence":"additional","affiliation":[{"name":"Department of Biology, Science Faculty Selcuk University Konya Turkey"},{"name":"Department of Pharmacy, Botanic Garden \u201cGiardino dei Semplici\u201d Universit\u00e0 degli Studi \u201cGabriele d'Annunzio\u201d Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Koyuncu","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine Harran University Sanliurfa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zg\u00fcr","family":"Y\u00fcksekda\u011f","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Botanic Garden \u201cGiardino dei Semplici\u201d Universit\u00e0 degli Studi \u201cGabriele d'Annunzio\u201d Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda de la Luz","family":"C\u00e1diz\u2010Gurrea","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Sciences University of Granada, Fuentenueva s\/n Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11030552"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2022.01.022"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.03.001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23137263"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2020.107686"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2589-3777(19)30018-7"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chmed.2020.03.002"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2020.09.010"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fochx.2023.100640"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11112171"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28093678"},{"key":"e_1_2_7_13_1","unstructured":"D. A.Snijman Plants of the Greater Cape Floristic Region. 2: The Extra Cape flora South African National Biodiversity Institute Cape Town South Africa2013."},{"key":"e_1_2_7_14_1","unstructured":"B.\u2010E.Van Wyk N.Gericke People's plants: A guide to useful plants of Southern Africa Briza publications Pretoria South Africa2000."},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2005.05.046"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.enzmictec.2016.10.019"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbp.2010.04.008"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2020.08.022"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920008786927794"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5266(02)00264-9"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-22144-6_57"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf990146l"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11010011"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/10942912.2011.595864"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2015.11.008"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ffj.1875"},{"key":"e_1_2_7_27_1","doi-asserted-by":"crossref","unstructured":"M.Moghaddam L.Mehdizadeh Soft chemistry and food fermentation Elsevier Oxford United Kingdom2017 pp.379.","DOI":"10.1016\/B978-0-12-811412-4.00013-8"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2018.12.018"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)00176-X"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2013.05.013"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2010.02.061"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/pr8060694"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2006.11.021"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/pca.1246"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2013.02.092"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2010.10.016"},{"issue":"1","key":"e_1_2_7_37_1","first-page":"43","volume":"2","author":"Karamian R.","year":"2013","journal-title":"J. Med. Plants By\u2010product"},{"key":"e_1_2_7_38_1","doi-asserted-by":"crossref","unstructured":"A.Mukne S.Nair M.Momin NanoAgroceuticals & NanoPhytoChemicals CRC Press New York USA2018 pp.99.","DOI":"10.1201\/9781351139281-6"},{"key":"e_1_2_7_39_1","doi-asserted-by":"crossref","unstructured":"S.Sen R.Chakraborty Gastrointestinal Tissue Elsevier Oxford United Kingdom2017 pp.259.","DOI":"10.1016\/B978-0-12-805377-5.00019-9"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-11-167"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24050982"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.20546\/ijcmas.2018.702.347"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.5530\/pj.2019.11.37"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7384735"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-020-02689-3"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2ob25174d"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf030723c"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2007.05.002"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf0003911"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8TB00107C"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24061123"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.22023"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules18044282"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3848084"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf0256135"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0309-1740(01)00053-5"},{"issue":"1","key":"e_1_2_7_57_1","first-page":"457","volume":"10","author":"Bhutkar M.","year":"2012","journal-title":"Int. J. Chem. Sci"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms12063757"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2019.03.033"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jams.2012.10.005"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.10-116"},{"issue":"1","key":"e_1_2_7_62_1","first-page":"109","volume":"9","author":"Javed Ahamad A.","year":"2021","journal-title":"ARO\u2010The Sci. J. Koya Univ"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants11172226"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-11-81"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2017.10.002"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.03.060"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40203-021-00099-6"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2022.121797"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145705005833"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182005008206"},{"key":"e_1_2_7_71_1","unstructured":"H.Soreq The Multileveled Regulation of the Human Cholinesterase Genes and Their Protein Products Phd Thesis Hebrew University Jerusalem Israel (1993)."},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)01303-6"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-0102(01)00289-9"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2013.09.050"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.31925\/farmacia.2022.3.13"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.11.090"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(97)00393-2"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology11020307"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2004.03.001"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2015.05.003"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmab007"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-93458-4"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.26650\/IstanbulJPharm.2019.0076"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159x18666201119153807"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2023.103174"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-016-1484-3"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0RA06047J"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma5091661"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.19.2781"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12167"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-005-5054-y"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.12996"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2016.02.004"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25163750"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202300547"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2022.111883"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S147740"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6565"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13446"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40659-019-0214-y"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.4314\/tjpr.v13i9.26"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants12051132"},{"issue":"1","key":"e_1_2_7_103_1","first-page":"22","volume":"8","author":"Ferda A.","year":"2017","journal-title":"J. Clin. Exp. Investig"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2017.1314511"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers9050052"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2926"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/852748"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1016451108"},{"key":"e_1_2_7_109_1","doi-asserted-by":"publisher","DOI":"10.4314\/ajtcam.v11i2.37"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00290"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac956"},{"key":"e_1_2_7_112_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz382"},{"key":"e_1_2_7_113_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac1046"},{"key":"e_1_2_7_114_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"},{"key":"e_1_2_7_115_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1131"},{"key":"e_1_2_7_116_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz931"},{"key":"e_1_2_7_117_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa970"},{"key":"e_1_2_7_118_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt285"}],"container-title":["Archiv der Pharmazie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ardp.202300728","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T13:32:57Z","timestamp":1715175177000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ardp.202300728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,5]]},"references-count":117,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/ardp.202300728"],"URL":"https:\/\/doi.org\/10.1002\/ardp.202300728","archive":["Portico"],"relation":{},"ISSN":["0365-6233","1521-4184"],"issn-type":[{"value":"0365-6233","type":"print"},{"value":"1521-4184","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,5]]},"assertion":[{"value":"2023-12-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2300728"}}