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Electrospun membranes are particularly interesting for wound dressing applications because they mimic the extracellular matrix of healthy skin. In this study, a potential wound healing platform capable of inducing synergistic antibacterial and antioxidation activities was developed by incorporating bio\u2010active rosmarinic acid\u2010hydroxyapatite hybrid (HAP\u2010RA) with different contents (0.5, 1, and 1.5 wt.%) into the electrospun polyamide 6 (PA6) nanofibers. Then, polyethylene glycol (PEG) was introduced to the nanofibrous composite to improve the biocompatibility and biodegradability of the dressing. The results indicated that the hydrophilicity, water uptake, biodegradability, and mechanical properties of the obtained PA6\/PEG\/HAP\u2010RA nanofibrous composite enhanced at 1 wt.% of HAP\u2010RA. The nanofibrous composite had excellent antibacterial activity. The antioxidation potential of the samples was assessed in vitro. The MTT assay performed on the L929 cell line confirmed the positive effects of the nanofibrous scaffold on cell viability and proliferation. According to the results, the PA6\/PEG\/HAP\u2010RA nanofibrous composite showed the desirable physiochemical and biological properties besides antibacterial and antioxidative capabilities, making it a promising candidate for further studies in wound healing applications.<\/jats:p>","DOI":"10.1002\/ardp.202400001","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T13:30:30Z","timestamp":1715779830000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A bi\u2010functional nanofibrous composite membrane for wound healing applications"],"prefix":"10.1002","volume":"357","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6299-0220","authenticated-orcid":false,"given":"Mohamadreza","family":"Shakiba","sequence":"first","affiliation":[{"name":"Department of Chemistry Amirkabir University of Technology Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehrab","family":"Pourmadadi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, School of Chemical Engineering, College of Engineering University of Tehran Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyede M.","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Department of Chemistry Amirkabir University of Technology Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7442-3549","authenticated-orcid":false,"given":"Ashkan","family":"Bigham","sequence":"additional","affiliation":[{"name":"Institute of Polymers, Composites, and Biomaterials, National Research Council (IPCB\u2010CNR) Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erfan","family":"Rahmani","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Delaware Newark Delaware USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Sheikhi","sequence":"additional","affiliation":[{"name":"Polymer Chemistry Research Laboratory, Department of Chemistry University of Isfahan Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zohreh","family":"Pahnavar","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Chemistry University of Mazandaran Babolsar Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amin","family":"Foroozandeh","sequence":"additional","affiliation":[{"name":"Department of Chemistry Amirkabir University of Technology Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Tajiki","sequence":"additional","affiliation":[{"name":"Department of Chemistry Amirkabir University of Technology Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirzad","family":"Jouybar","sequence":"additional","affiliation":[{"name":"Department of Chemistry Amirkabir University of Technology Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majid","family":"Abdouss","sequence":"additional","affiliation":[{"name":"Department of Chemistry Amirkabir University of Technology Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2013.0506"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612827666210714102304"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.115839"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10800-024-02075-2"},{"key":"e_1_2_8_6_1","unstructured":"M. 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