{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T16:36:09Z","timestamp":1774974969987,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The emergence and global spread of methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA) pose a serious threat to public health, underscoring the urgent need for novel antibacterial interventions. Here, we screened 18 newly synthesized <jats:italic>N<\/jats:italic>,<jats:italic>N<\/jats:italic>\u2019\u2010diarylurea derivatives to identify compounds with activity against MRSA. Our investigations led to the discovery of a small molecule, SCB\u201024, which exhibited promising antimicrobial activity against MRSA USA300. Notably, SCB\u201024 demonstrated high activity even in the presence of 10% fetal bovine serum and showed excellent selectivity for bacterial over mammalian cells. SCB\u201024 also showed potent activity against various MRSA strains, including those resistant to second\u2010 and third\u2010line antibiotics. Importantly, the efficacy of SCB\u201024 was inferior to that of vancomycin in MRSA\u2010infected <jats:italic>Galleria mellonella<\/jats:italic> larvae. Overall, our findings suggest that SCB\u201024 has great potential as a new therapeutic for multidrug\u2010resistant <jats:italic>S. aureus<\/jats:italic> infections.<\/jats:p>","DOI":"10.1002\/ardp.202400047","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T19:38:46Z","timestamp":1714505926000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Discovery of <i>N<\/i>,<i>N<\/i>'\u2010diarylurea molecules with activity against multidrug\u2010resistant <i>Staphylococcus aureus<\/i>"],"prefix":"10.1002","volume":"357","author":[{"given":"Hui\u2010Hui","family":"Yeo","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine National Taiwan University Taipei 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