{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:48:32Z","timestamp":1792723712065,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T00:00:00Z","timestamp":1714867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lithium induces nephrogenic diabetes insipidus (NDI) and microcystic chronic kidney disease (CKD). As previous clinical studies suggest that NDI is dose\u2010dependent and CKD is time\u2010dependent, we investigated the effect of low exposition to lithium in a long\u2010term experimental rat model. Rats were fed with a normal diet (control group),\u00a0with the addition of lithium (Li<jats:sup>+<\/jats:sup> group), or with lithium and amiloride (Li<jats:sup>+<\/jats:sup>\/Ami group) for 6 months, allowing obtaining low plasma lithium concentrations (0.25\u2009\u00b1\u20090.06 and 0.43\u2009\u00b1\u20090.16\u2009mmol\/L, respectively). Exposition to low concentrations of plasma lithium levels prevented NDI but not microcystic dilations of kidney tubules, which were identified as collecting ducts (CDs) on immunofluorescent staining. Both hypertrophy, characterized by an increase in the ratio of nuclei per tubular area, and microcystic dilations were observed. The ratio between principal cells and intercalated cells was higher in microcystic than in hypertrophied tubules. There was no correlation between AQP2 messenger RNA levels and cellular remodeling of the CD. Additional amiloride treatment in the Li<jats:sup>+<\/jats:sup>\/Ami group did not allow consistent morphometric and cellular composition changes compared to the Li<jats:sup>+<\/jats:sup> group. Low exposition to lithium prevented overt NDI but not microcystic dilations of the CD, with differential cellular composition in hypertrophied and microcystic CDs, suggesting different underlying cellular mechanisms.<\/jats:p>","DOI":"10.1002\/ardp.202400063","type":"journal-article","created":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T14:05:10Z","timestamp":1714917910000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Low exposition to lithium prevents nephrogenic diabetes insipidus but not microcystic dilations of the collecting ducts in long\u2010term rat model"],"prefix":"10.1002","volume":"357","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5803-0163","authenticated-orcid":false,"given":"Nahid","family":"Tabibzadeh","sequence":"first","affiliation":[{"name":"Laboratoire de Physiologie R\u00e9nale et Tubulopathies, Centre de Recherche des Cordeliers, INSERM Sorbonne Universit\u00e9, Universit\u00e9 Paris Cit\u00e9 Paris France"},{"name":"EMR 8228 Unit\u00e9 M\u00e9tabolisme et Physiologie R\u00e9nale, CNRS Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3424-8007","authenticated-orcid":false,"given":"Mathieu","family":"Klein","sequence":"additional","affiliation":[{"name":"Inserm UMRS\u20101144 Universit\u00e9 Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Try","sequence":"additional","affiliation":[{"name":"Laboratoire de Physiologie R\u00e9nale et Tubulopathies, Centre de Recherche des Cordeliers, INSERM Sorbonne Universit\u00e9, Universit\u00e9 Paris Cit\u00e9 Paris France"},{"name":"EMR 8228 Unit\u00e9 M\u00e9tabolisme et Physiologie R\u00e9nale, CNRS Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00ebl","family":"Poupon","sequence":"additional","affiliation":[{"name":"Department of Biological Toxicology, AP\u2010HP, Lariboisi\u00e8re Hospital University Paris VII Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Houillier","sequence":"additional","affiliation":[{"name":"Laboratoire de Physiologie R\u00e9nale et Tubulopathies, Centre de Recherche des Cordeliers, INSERM Sorbonne Universit\u00e9, Universit\u00e9 Paris Cit\u00e9 Paris France"},{"name":"EMR 8228 Unit\u00e9 M\u00e9tabolisme et Physiologie R\u00e9nale, CNRS Paris France"},{"name":"Assistance Publique\u2010H\u00f4pitaux de Paris, H\u00f4pital Europ\u00e9en Georges Pompidou, Service de Physiologie Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Klein","sequence":"additional","affiliation":[{"name":"Centre d'Histologie, d'Imagerie et de Cytom\u00e9trie (CHIC), Centre de Recherche des Cordeliers, INSERM Sorbonne Universit\u00e9, Universit\u00e9 de Paris Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydie","family":"Cheval","sequence":"additional","affiliation":[{"name":"Laboratoire de Physiologie R\u00e9nale et Tubulopathies, Centre de Recherche des Cordeliers, INSERM Sorbonne Universit\u00e9, Universit\u00e9 Paris Cit\u00e9 Paris France"},{"name":"EMR 8228 Unit\u00e9 M\u00e9tabolisme et Physiologie R\u00e9nale, CNRS Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Crambert","sequence":"additional","affiliation":[{"name":"Laboratoire de Physiologie R\u00e9nale et Tubulopathies, Centre de Recherche des Cordeliers, INSERM Sorbonne Universit\u00e9, Universit\u00e9 Paris Cit\u00e9 Paris France"},{"name":"EMR 8228 Unit\u00e9 M\u00e9tabolisme et Physiologie R\u00e9nale, CNRS Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1101-2641","authenticated-orcid":false,"given":"Samia","family":"Lasaad","sequence":"additional","affiliation":[{"name":"Laboratoire de Physiologie R\u00e9nale et Tubulopathies, Centre de Recherche des Cordeliers, INSERM Sorbonne Universit\u00e9, Universit\u00e9 Paris Cit\u00e9 Paris France"},{"name":"EMR 8228 Unit\u00e9 M\u00e9tabolisme et Physiologie R\u00e9nale, CNRS Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Chevillard","sequence":"additional","affiliation":[{"name":"Inserm UMRS\u20101144 Universit\u00e9 Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2522-2764","authenticated-orcid":false,"given":"Bruno","family":"Megarbane","sequence":"additional","affiliation":[{"name":"Inserm UMRS\u20101144 Universit\u00e9 Paris Cit\u00e9 Paris France"},{"name":"Department of Medical and Toxicological Critical Care Lariboisi\u00e8re Hospital, Federation of Toxicology, APHP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.2.217"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61828-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(14)70314-1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2019.01.006"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61516-X"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61842-0"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00182.2012"},{"issue":"5","key":"e_1_2_9_9_1","first-page":"526","volume":"50","author":"Kling M. 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